| IED ID |
IndEnz0001000041 |
| Enzyme Type ID |
amylase000041 |
| Protein Name |
Ras-related protein Rab-26
|
| Gene Name |
RAB26 |
| Organism |
Homo sapiens (Human) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Primates
Haplorrhini
Simiiformes
Catarrhini
Hominoidea (apes)
Hominidae (great apes)
Homininae
Homo
Homo sapiens (Human)
|
| Enzyme Sequence |
MSRKKTPKSKGASTPAASTLPTANGARPARSGTALSGPDAPPNGPLQPGRPSLGGGVDFYDVAFKVMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFRNKVLDVDGVKVKLQMWDTAGQERFRSVTHAYYRDAHALLLLYDVTNKASFDNIQAWLTEIHEYAQHDVALMLLGNKVDSAHERVVKREDGEKLAKEYGLPFMETSAKTGLNVDLAFTAIAKELKQRSMKAPSEPRFRLHDYVKREGRGASCCRP |
| Enzyme Length |
256 |
| Uniprot Accession Number |
Q9ULW5 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland. {ECO:0000269|PubMed:20038531, ECO:0000269|PubMed:23105096}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
NP_BIND 70..78; /note=GTP; /evidence=ECO:0000269|Ref.10; NP_BIND 119..123; /note=GTP; /evidence=ECO:0000269|Ref.10; NP_BIND 177..180; /note=GTP; /evidence=ECO:0000269|Ref.10; NP_BIND 207..209; /note=GTP; /evidence=ECO:0000269|Ref.10 |
| Features |
Alternative sequence (1); Beta strand (6); Chain (1); Compositional bias (1); Erroneous initiation (1); Helix (6); Lipidation (2); Motif (1); Mutagenesis (3); Nucleotide binding (4); Region (1); Sequence conflict (1); Turn (1) |
| Keywords |
3D-structure;Alternative splicing;Cytoplasmic vesicle;GTP-binding;Golgi apparatus;Lipoprotein;Membrane;Nucleotide-binding;Prenylation;Protein transport;Reference proteome;Transport |
| Interact With |
P18089; Q5TD97; Q14525; O43482; Q9H9P5-5 |
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:23105096}; Lipid-anchor {ECO:0000269|PubMed:23105096}; Cytoplasmic side {ECO:0000269|PubMed:23105096}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305|PubMed:23105096}; Lipid-anchor {ECO:0000305|PubMed:23105096}; Cytoplasmic side {ECO:0000305|PubMed:23105096}. Note=Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location. {ECO:0000250|UniProtKB:P51156}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
X-ray crystallography (1) |
| Cross Reference PDB |
2G6B;
|
| Mapped Pubmed ID |
11141079;
11389151;
11675392;
1648736;
16696853;
17114793;
17411337;
18532927;
19603039;
19913121;
20628086;
24023390;
24413166;
25341920;
25643395;
26496610;
33731709;
7957092;
7991565;
8164745;
8349690;
8375503;
8513495;
8631982;
8662963;
8836150;
|
| Motif |
MOTIF 93..101; /note=Effector region; /evidence=ECO:0000250 |
| Gene Encoded By |
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| Mass |
27,900 |
| Kinetics |
|
| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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