| IED ID | IndEnz0001000185 |
| Enzyme Type ID | amylase000185 |
| Protein Name |
Catabolite control protein A Glucose-resistance amylase regulator |
| Gene Name | ccpA alsA amyR graR BSU29740 |
| Organism | Bacillus subtilis (strain 168) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Bacillaceae Bacillus Bacillus subtilis group Bacillus subtilis Bacillus subtilis subsp. subtilis Bacillus subtilis (strain 168) |
| Enzyme Sequence | MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIERLGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQNMEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAIDYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVAEGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFDNTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS |
| Enzyme Length | 334 |
| Uniprot Accession Number | P25144 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | DNA_BIND 6..25; /note=H-T-H motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU00111 |
| EC Number | |
| Enzyme Function | FUNCTION: Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. Interacts with either P-Ser-HPr or P-Ser-Crh, leading to the formation of a complex that binds to DNA at the catabolite-response elements (cre). Binding to DNA allows activation or repression of many different genes and operons. {ECO:0000269|PubMed:10559165, ECO:0000269|PubMed:11557150, ECO:0000269|PubMed:1904524, ECO:0000269|PubMed:21106498, ECO:0000269|PubMed:7665492}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (16); Chain (1); DNA binding (1); Domain (1); Helix (15); Turn (1) |
| Keywords | 3D-structure;Activator;DNA-binding;Reference proteome;Repressor;Transcription;Transcription regulation |
| Interact With | P39779; P08877; P20429 |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (5) |
| Cross Reference PDB | 1ZVV; 2FEP; 3OQM; 3OQN; 3OQO; |
| Mapped Pubmed ID | 21630458; 22512862; |
| Motif | |
| Gene Encoded By | |
| Mass | 36,940 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |