| IED ID |
IndEnz0001000330 |
| Enzyme Type ID |
amylase000330 |
| Protein Name |
Syncollin
|
| Gene Name |
Sycn |
| Organism |
Mus musculus (Mouse) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Glires (Rodents and rabbits)
Rodentia
Myomorpha (mice and others)
Muroidea
Muridae
Murinae
Mus
Mus
Mus musculus (Mouse)
|
| Enzyme Sequence |
MSLLCPLLLALALVAVPGAHGNCPVPADLKKSDGTRTCARLYEKSDPYYDNCCQGPVLSVEPGTDLPYLPSGWSNTASSLVVGQRCEITVWSLPGKHGKTRKFTAGSYPRLEEYRKGIFGDWSDSISALYCKCY |
| Enzyme Length |
134 |
| Uniprot Accession Number |
Q8VCK7 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues. {ECO:0000269|PubMed:11839820, ECO:0000269|PubMed:15040787, ECO:0000269|PubMed:15462671}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Sequence conflict (1); Signal peptide (1) |
| Keywords |
Cytoplasmic vesicle;Disulfide bond;Exocytosis;Membrane;Reference proteome;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Zymogen granule membrane {ECO:0000250|UniProtKB:O35775}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35775}; Lumenal side {ECO:0000250|UniProtKB:O35775}. Zymogen granule lumen {ECO:0000250|UniProtKB:O35775}. Note=Associated in a cholesterol-dependent manner with lipid rafts of zymogen granule membranes. {ECO:0000250|UniProtKB:O35775}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: Contains intrachain disulfide bonds. {ECO:0000250}. |
| Signal Peptide |
SIGNAL 1..21; /evidence=ECO:0000250 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
11217851;
12466851;
21267068;
25179606;
25186293;
30590051;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
14,595 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|