| IED ID | IndEnz0001000334 |
| Enzyme Type ID | amylase000334 |
| Protein Name |
Neutral and basic amino acid transport protein rBAT NBAT D2h Solute carrier family 3 member 1 b 0,+ -type amino acid transport protein |
| Gene Name | SLC3A1 RBAT |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MAEDKSKRDSIEMSMKGCQTNNGFVHNEDILEQTPDPGSSTDNLKHSTRGILGSQEPDFKGVQPYAGMPKEVLFQFSGQARYRIPREILFWLTVASVLVLIAATIAIIALSPKCLDWWQEGPMYQIYPRSFKDSNKDGNGDLKGIQDKLDYITALNIKTVWITSFYKSSLKDFRYGVEDFREVDPIFGTMEDFENLVAAIHDKGLKLIIDFIPNHTSDKHIWFQLSRTRTGKYTDYYIWHDCTHENGKTIPPNNWLSVYGNSSWHFDEVRNQCYFHQFMKEQPDLNFRNPDVQEEIKEILRFWLTKGVDGFSLDAVKFLLEAKHLRDEIQVNKTQIPDTVTQYSELYHDFTTTQVGMHDIVRSFRQTMDQYSTEPGRYRFMGTEAYAESIDRTVMYYGLPFIQEADFPFNNYLSMLDTVSGNSVYEVITSWMENMPEGKWPNWMIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLNILYTSC |
| Enzyme Length | 685 |
| Uniprot Accession Number | Q07837 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule. {ECO:0000269|PubMed:11318953, ECO:0000269|PubMed:7686906, ECO:0000269|PubMed:8486766, ECO:0000269|PubMed:8663184}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (11); Beta strand (28); Chain (1); Compositional bias (1); Glycosylation (6); Helix (28); Modified residue (1); Natural variant (54); Region (1); Topological domain (2); Transmembrane (1); Turn (12) |
| Keywords | 3D-structure;Alternative splicing;Amino-acid transport;Cystinuria;Disease variant;Disulfide bond;Glycoprotein;Membrane;Phosphoprotein;Reference proteome;Signal-anchor;Transmembrane;Transmembrane helix;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12167606}; Single-pass type II membrane protein {ECO:0000269|PubMed:12167606}. |
| Modified Residue | MOD_RES 10; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q64319 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | Electron microscopy (4) |
| Cross Reference PDB | 6LI9; 6LID; 6YUP; 6YUZ; |
| Mapped Pubmed ID | 10798361; 11157794; 11458794; 12060600; 12239244; 12372889; 12820697; 14531788; 14561219; 14991253; 15691362; 15818800; 15818801; 15818802; 16358225; 17010017; 18234729; 18332091; 18752446; 18778962; 20146678; 20800603; 21255007; 22796000; 23794250; 24045899; 24449952; 24824759; 25964309; 26123750; 26537754; 26540609; 26837681; 28166740; 28382174; 28646536; 28689648; 28812535; 30069816; 30146843; 32494597; 32817565; 33349102; |
| Motif | |
| Gene Encoded By | |
| Mass | 78,852 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |