| IED ID | IndEnz0001000412 |
| Enzyme Type ID | amylase000412 |
| Protein Name |
Cell wall alpha-1,3-glucan synthase ags1 EC 2.4.1.183 Cell wall alpha-1,4-glucan synthase |
| Gene Name | ags1 mok1 SPCC1281.01 SPCC17A7.01 SPCC338.01c |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota Taphrinomycotina Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces Schizosaccharomyces pombe (Fission yeast) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Enzyme Sequence | MHGLQGLCFRRAVIALALLLFHSVFAAPYSEDEEPWNLNQNKNASSVLEYSGEWADHDFFPSPDNWRMSFITVILDRWYDGDPSNNDIEKTPFEYDISEVSFRNGGDIVGLELSLDYLEGLGTQGIYIAGTPFVNMPWGADQYSPLDYTILDHHLGTIDQWRSTITAMHERGMYLVVDLTVATLGDLIGMVGHLNDTSGVDFNLNEYNAMWKTSEYRYVDFNFTNVYNTSCEYPRFWGEDGGPVSIQFKGCYVSDFDHYGDTEAFGSHPDWQRQLSKFASVQDRLRDWKPDVAEKLMHLSCLVISMLDVDGFRIDKATQMTADFIVDWSMYVRECAAKYNKKNFLIVGEVTGSSSYGSIYYNRGRQPDQRPPNVTAAFNYTSDESQYSLRDSDHYGFDGSAFHYSIYRALLRFLGMDSKMEIDFDVSSVLTTAWNGIQINEDAVNINTGTVEPLHMYGVANHDVFRWGAIENGTARLILGTMITSLLFPGIPLLYYGDEQGMYVLDNSANNYLYGRQAMNSARAWYIHGCYNGSATSYPTVDLSPAQRGCQDSWNYLDHFDIASAHRNVYRNIHSIRRHYLSLSEGWRFDHIANWTDDVYFPDSQPYASPMGLYSVLRGPMKEIQDFDSITNASNVSKSEVWVLYANRNDTHLWSYDCTDEDSAIIGPWKSGTTLRNLIYPYDTIELEDSWNSSWGCIPNIELDPYAFKLYVPEEDFIENDPIITSLTPEHDARVVASGNEIDLTIEFSRSMDCDSIKNALSVVSSTRPKNTTAVIDVDSSFCRNYSEDASTSLHGQTAGRFAWYGTLTNIDPGIHRISLKSVPTSDFSSRTLSTDNFLIRVGSTNNPIVHYSANYSDTLLIMQDGDLYINHSAPGAVLFRYSTDFQSHWSDWEEYNGGLTKVQASNWTGTRRQGWEGHHIHVQYWSDLGGSANHMQQSDYGFKYRRFLPHMFLEGDFNEYGYDSGVENRFLQKSDFYWEAGFISETYPAAIQLNVWGMNPDGIPDKTRVYGSQGNSTVLSRSDPASLVGNNITIYHPPPHGYLSYKILLRDDDMIYRLAPSGEWGVSIAIYVLCIVIPPLSAIVVSWAFKNSFYTVKFNKHGNNDLGKFYPLKSLVPFRKKNDLDSPAKVTPVVSGVSARKKKCVLIATLEYDITDWKIRIKIGGLGVMAQLMAQHLKHEDLVWVVPCVGDVVYPEAEEASPIEVKIIDQTYTINVYHHYLDNIKYVLLDAPVFRRQTSKEPYPARMDDLGSAIFYSAWNQCIAEVIRRNPIDIYHINDYHGALAPCYLLPDIIPCALSLHNAEFQGLWPLRTPEEKEEVCAVYNISQRVCTKYVQFGNVFNLLHAAVSYIRIHQKGFGAVGVSNKYGKRSWARYPIFWGLKKIGKLPNPDPTDTDEIVDDKAVAITDIDPDMEKSKVEHKRLAQEWAGLEVNEKYDLLVFVGRWSSQKGIDLIADIAPSLLESYKVQLICVGPIIDLYGKFAAEKLDVLQKKYPTRVFSQPKFTQLPPYIFSGADFALIPSRDEPFGLVAVEFGRKGALGIGARVGGLGQMPGWWYSVESSATPHLLKQFEQACQQALSSSQRTRARLRARSAKQRFPVSQWKAKLEALTDGCIKCSQKYGRNSRSRSSFYSLIHESFSRSSEVLPTSSDTNLDAKRAEEAEMIMIETPPTAEANTGAKLDRSLSLGSRRGPGHTTEDDASDGLDTIQEESMTAGDSTSGGSDISRYRAERLNPDSHSPSEYSFDSGDYEFDPQRSYYYDDLFDDDTTIRNAPSFRPQMGSFDAEHAVGATFSQDDLSDPARSVDSDSVSPPLPPFVAGSNPNARNNNNPYFYGNLHTESSLSLASVMSGKEKRDFSLTRVEETFTDEDGQALRSFSEKLQKLNAKNSKDDLCIEQYLMKSERSFFHERRAIKLGLQKPNKLHVNELSSHSGTEESESLSNGQTSYDDIIAMTDESNYTQLGDDDFKTIHGLKKFMLFKIYDWPIYSIFLALGQILAATAYQLTLFTGTSNIQTYEIYSVCAFFIGASFVWWFMFARLPSYYVLSIPWLFYAVALFLVGLPAFDTVAPGRVWITNVAAWIYAIASASGSIFFSLNFGEEGAVQTRIWVFRACLVQGVQQVWSAALWYWGAHLNKRLTAGEANTFKMSPAIPSITWPLSAVSILIFALLFKGLPEYYRQLSGSIPAFYKSLLRRKLVVWFCISVFLQNFWLSSLNGRSWSYLWDIGNIHQWQIFLLIVAFYIVLWALLLGVLAWISRTHSWIICVFGVGLGAPRWLQQFWATSNIGLYLPWAGYSGPYLGRTLWLWLGVLDAIQSVGIGMILLQTLTRRHVASTLMTGQIVGAVATMIGRGASPNREGPANVFIDFTKWNHGDGSSILASAPFWINIICQLAICVGYLAFFRRENLSRP |
| Enzyme Length | 2410 |
| Uniprot Accession Number | Q9USK8 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:19749, Rhea:RHEA-COMP:11150, Rhea:RHEA-COMP:11151, ChEBI:CHEBI:15378, ChEBI:CHEBI:28100, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.183; |
| DNA Binding | |
| EC Number | 2.4.1.183 |
| Enzyme Function | FUNCTION: Required for alpha-1,3-glucan and alpha-1,4-glucan production which are required for cell wall synthesis. {ECO:0000269|PubMed:17472966}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Modified residue (6); Mutagenesis (1); Region (2); Sequence conflict (3) |
| Keywords | Cell wall biogenesis/degradation;Glycosyltransferase;Multifunctional enzyme;Phosphoprotein;Reference proteome;Transferase |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 1643; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18257517; MOD_RES 1644; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18257517; MOD_RES 1651; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18257517; MOD_RES 1653; /note=Phosphothreonine; /evidence=ECO:0000269|PubMed:18257517; MOD_RES 1738; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18257517; MOD_RES 1812; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18257517 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12206652; 16420355; 18793338; 19547744; 20473289; 21712547; 22633491; 22891259; 23297348; 23697806; 23934882; 24763107; 25720772; 26412298; 27298342; 29996109; 30726745; 32101745; 32142608; 34296454; |
| Motif | |
| Gene Encoded By | |
| Mass | 272,106 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:19749 |
| Cross Reference Brenda | 2.4.1.B3; |