| IED ID |
IndEnz0001000482 |
| Enzyme Type ID |
amylase000482 |
| Protein Name |
Alpha-amylase inhibitor magnificamide
|
| Gene Name |
|
| Organism |
Heteractis magnifica (Magnificent sea anemone) (Radianthus magnifica) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Cnidaria
Anthozoa (anthozoans)
Hexacorallia
Actiniaria (sea anemones)
Stichodactylidae
Heteractis
Heteractis magnifica (Magnificent sea anemone) (Radianthus magnifica)
|
| Enzyme Sequence |
SEGTSCYIYHGVYGICKAKCAEDMKAMAGMGVCEGDLCCYKTPW |
| Enzyme Length |
44 |
| Uniprot Accession Number |
C0HK71 |
| Absorption |
|
| Active Site |
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| Activity Regulation |
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| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
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| DNA Binding |
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| EC Number |
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| Enzyme Function |
FUNCTION: Mammalian alpha-amylase (AMY2A) inhibitor (PubMed:29191747, PubMed:31546678). The recombinant peptide inhibits porcine pancreatic (Ki=0.17 nM) and human saliva alpha-amylases (Ki=7.7 nM) (PubMed:31546678). It does not show antimicrobial (tested on fungi and bacteria) or channel modulating activities (tested on 18 voltage-gated sodium and potassium channles) (PubMed:31546678). {ECO:0000269|PubMed:29191747, ECO:0000269|PubMed:31546678}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
|
| nucleotide Binding |
|
| Features |
Disulfide bond (3); Peptide (1); Region (1) |
| Keywords |
Alpha-amylase inhibitor;Direct protein sequencing;Disulfide bond;Pharmaceutical;Secreted |
| Interact With |
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| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29191747}. |
| Modified Residue |
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| Post Translational Modification |
|
| Signal Peptide |
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| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
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| Gene Encoded By |
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| Mass |
4,775 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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