| IED ID |
IndEnz0001000484 |
| Enzyme Type ID |
amylase000484 |
| Protein Name |
Alpha-amylase inhibitor helianthamide
|
| Gene Name |
|
| Organism |
Stichodactyla helianthus (Sun anemone) (Stoichactis helianthus) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Cnidaria
Anthozoa (anthozoans)
Hexacorallia
Actiniaria (sea anemones)
Stichodactylidae
Stichodactyla
Stichodactyla helianthus (Sun anemone) (Stoichactis helianthus)
|
| Enzyme Sequence |
ESGNSCYIYHGVSGICKASCAEDEKAMAGMGVCEGHLCCYKTPW |
| Enzyme Length |
44 |
| Uniprot Accession Number |
A0A0X1KGZ5 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Specific pancreatic alpha-amylase (AMY2A) inhibitor. The recombinant peptide inhibits human pancreatic (Ki=0.01 nM) and porcine pancreatic alpha-amylases (Ki=0.1 nM). {ECO:0000269|PubMed:27066537}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (3); Region (1) |
| Keywords |
3D-structure;Alpha-amylase inhibitor;Direct protein sequencing;Disulfide bond;Pharmaceutical;Secreted |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:C0HK71}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
X-ray crystallography (1) |
| Cross Reference PDB |
4X0N;
|
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
4,690 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|