Detail Information for IndEnz0001000801
IED ID IndEnz0001000801
Enzyme Type ID amylase000801
Protein Name 1,4-alpha-glucan-branching enzyme
EC 2.4.1.18
Brancher enzyme
Glycogen-branching enzyme
Gene Name GBE1
Organism Equus caballus (Horse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Perissodactyla (odd-toed ungulates) Equidae (horses) Equus Equus Equus caballus (Horse)
Enzyme Sequence MAAPAARADGSDAALAAALADVPDLGRLLEVDPYLKPYAPDFQRRYNRFSQTLDNIGKNEGGIDKFSRGYESFGVHRCADGGLYCKEWAPGAEGVFLTGDFNDWNPFSYPYKKLDYGKWDLYIPPKPNKSLLVPHGSKLKVVIRSKSGEILYRISPWAKYVVRESGNVNYDWIHWDPEQPYKFKHSRPKKPRSLRIYESHVGISSHEGKIASYKHFTCNVLPRIKGLGYNCIQMMAIMEHAYYASFGYQITSFFAASSRYGTPEELKELVDTAHSMGITVLLDVVHSHASKNSEDGLNMFDGTDSCYFHSGPRGTHDLWDSRLFIYSSWEVLRFLLSNIRWWLEEYGFDGFRFDGVTSMLYHHHGIGASFSGDYHEYFGLQVDEDALTYLMLANHLVHTLYPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLVKEFKDEDWNMGNIVYTLTNRRHLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHALGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMNKLEERCGWLSAPQAFVSEKHEGNKVIAFERAALLFIFNFHPSKSYTNYRVGTTLPGKFKIVLDSDAAEYGGHQRLDHNTDFFSEPYEHNERPSSLLVYIPSRVALILQNVDPPN
Enzyme Length 699
Uniprot Accession Number Q6EAS5
Absorption
Active Site ACT_SITE 354; /note=Nucleophile; /evidence=ECO:0000250; ACT_SITE 409; /note=Proton donor; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.; EC=2.4.1.18; Evidence={ECO:0000305|PubMed:15366377};
DNA Binding
EC Number 2.4.1.18
Enzyme Function FUNCTION: Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule. {ECO:0000250|UniProtKB:Q04446}.
Temperature Dependency
PH Dependency
Pathway PATHWAY: Glycan biosynthesis; glycogen biosynthesis. {ECO:0000269|PubMed:15366377}.
nucleotide Binding
Features Active site (2); Chain (1); Modified residue (1); Region (4)
Keywords Glycogen biosynthesis;Glycogen storage disease;Glycosyltransferase;Phosphoprotein;Reference proteome;Transferase
Interact With
Induction
Subcellular Location
Modified Residue MOD_RES 170; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:Q04446
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 79,978
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda 2.4.1.18;