| IED ID | IndEnz0001000899 |
| Enzyme Type ID | amylase000899 |
| Protein Name |
45 kDa calcium-binding protein Cab45 Stromal cell-derived factor 4 SDF-4 |
| Gene Name | SDF4 CAB45 PSEC0034 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MVWPWVAMASRWGPLIGLAPCCLWLLGAVLLMDASARPANHSSTRERVANREENEILPPDHLNGVKLEMDGHLNRGFHQEVFLGKDLGGFDEDAEPRRSRRKLMVIFSKVDVNTDRKISAKEMQRWIMEKTAEHFQEAMEESKTHFRAVDPDGDGHVSWDEYKVKFLASKGHSEKEVADAIRLNEELKVDEETQEVLENLKDRWYQADSPPADLLLTEEEFLSFLHPEHSRGMLRFMVKEIVRDLDQDGDKQLSVPEFISLPVGTVENQQGQDIDDNWVKDRKKEFEELIDSNHDGIVTAEELESYMDPMNEYNALNEAKQMIAVADENQNHHLEPEEVLKYSEFFTGSKLVDYARSVHEEF |
| Enzyme Length | 362 |
| Uniprot Accession Number | Q9BRK5 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 111..122; /note=1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; CA_BIND 150..161; /note=2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; CA_BIND 209..220; /note=3; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; CA_BIND 246..257; /note=4; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; CA_BIND 291..302; /note=5; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; CA_BIND 327..338; /note=6; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448 |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.; FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (7); Calcium binding (6); Chain (1); Domain (6); Frameshift (1); Glycosylation (1); Modified residue (5); Mutagenesis (3); Natural variant (2); Region (1); Sequence conflict (16); Signal peptide (1) |
| Keywords | Alternative splicing;Calcium;Cell membrane;Cell projection;Cytoplasm;Exocytosis;Glycoprotein;Golgi apparatus;Membrane;Metal-binding;Phosphoprotein;Reference proteome;Repeat;Signal |
| Interact With | P55212; P13473-2; O75400-2; Q9Y371 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus lumen {ECO:0000250|UniProtKB:Q61112}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:17442889}. Cell membrane {ECO:0000269|PubMed:17442889}. Cell projection, bleb. Note=Isoform 5 colocalizes with STX3 and STXBP1 isoform 2 at the plasma membrane and cell surface blebs. {ECO:0000269|PubMed:17442889}. |
| Modified Residue | MOD_RES 99; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:23186163; MOD_RES 193; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:24275569; MOD_RES 217; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:24275569; MOD_RES 265; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:24275569; MOD_RES 299; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:24275569 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..36; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 15231748; 17342744; 19513569; 19615732; 19773279; 19913121; 20562859; 20628086; 21150319; 21900206; 21911578; 21988832; 22190034; 23266954; 23416715; 23455922; 23602568; 24189400; 24810055; 25509878; 25772237; 25852190; 26496610; 27138253; 32422653; 34326834; |
| Motif | |
| Gene Encoded By | |
| Mass | 41,807 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |