| IED ID | IndEnz0001000900 |
| Enzyme Type ID | amylase000900 |
| Protein Name |
45 kDa calcium-binding protein Cab45 Stromal cell-derived factor 4 SDF-4 |
| Gene Name | Sdf4 Cab45 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MVWLVAMTSRQRSLCGLAAHGLWFLGLVLLMDATARPANHSFSRERAANRDENEIIPPDHLNGVKLEMDGHLNKDFHQEVFLGKDMDGFDEDSEPRRSRRKLMVIFSKVDVNTDRRISAKEMQHWIMEKTAEHFQEAVKENKLHFRAVDPDGDGHVSWDEYKVKFLASKGHNEREIADAIKNHEELKVDEETQEVLGNLRDRWYQADNPPADLLLTEDEFLSFLHPEHSRGMLKFMVKEIVRDLDQDGDKQLSLPEFISLPVGTVENQQGQDIDDNWVKDRKKEFEELIDSNHDGIVTMEELENYMDPMNEYNALNEAKQMIAIADENQNHHLEPEEILKYSEFFTGSKLMDYARNVHEEF |
| Enzyme Length | 361 |
| Uniprot Accession Number | Q91ZS3 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 110..121; /note=1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; CA_BIND 149..160; /note=2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; CA_BIND 208..219; /note=3; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; CA_BIND 245..256; /note=4; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; CA_BIND 290..301; /note=5; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; CA_BIND 326..337; /note=6; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448 |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: A membrane-associated isoform may be involved in the exocytosis of zymogens by pancreatic acini. May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000269|PubMed:17442889}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Calcium binding (6); Chain (1); Domain (6); Glycosylation (1); Modified residue (5); Region (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Alternative splicing;Calcium;Exocytosis;Glycoprotein;Golgi apparatus;Metal-binding;Phosphoprotein;Reference proteome;Repeat;Signal |
| Interact With | |
| Induction | INDUCTION: Down-regulated by ethanol. Down-regulated during the progression of cerebellum differentiation. {ECO:0000269|PubMed:18355758}. |
| Subcellular Location | SUBCELLULAR LOCATION: Golgi apparatus lumen {ECO:0000250|UniProtKB:Q61112}. |
| Modified Residue | MOD_RES 98; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9BRK5; MOD_RES 192; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:22673903; MOD_RES 216; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q9BRK5; MOD_RES 264; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q9BRK5; MOD_RES 298; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q9BRK5 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..35; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 42,075 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |