Detail Information for IndEnz0001000918
IED ID IndEnz0001000918
Enzyme Type ID amylase000918
Protein Name Cholecystokinin
CCK

Cleaved into: Cholecystokinin-39
CCK39
; Cholecystokinin-33
CCK33
; Cholecystokinin-22
CCK22
; Cholecystokinin-12
CCK12
; Cholecystokinin-8
CCK8
Gene Name Cck
Organism Rattus norvegicus (Rat)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat)
Enzyme Sequence MKCGVCLCVVMAVLAAGALAQPVVPVEAVDPMEQRAEEAPRRQLRAVLRPDSEPRARLGALLARYIQQVRKAPSGRMSVLKNLQGLDPSHRISDRDYMGWMDFGRRSAEDYEYPS
Enzyme Length 115
Uniprot Accession Number P01355
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Modified residue (4); Peptide (5); Propeptide (3); Signal peptide (1); Site (1)
Keywords Amidation;Cleavage on pair of basic residues;Hormone;Reference proteome;Secreted;Signal;Sulfation
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue MOD_RES 97; /note=Sulfotyrosine; /evidence=ECO:0000269|PubMed:8208365; MOD_RES 103; /note=Phenylalanine amide; /evidence=ECO:0000250|UniProtKB:P06307; MOD_RES 111; /note=Sulfotyrosine; /evidence=ECO:0000269|Ref.5; MOD_RES 113; /note=Sulfotyrosine; /evidence=ECO:0000269|Ref.5
Post Translational Modification PTM: The precursor is cleaved by proteases to produce a number of active cholecystokinins.; PTM: Sulfation of Tyr-97 is essential for receptor activation. {ECO:0000269|PubMed:8208365, ECO:0000269|Ref.5}.
Signal Peptide SIGNAL 1..20; /evidence=ECO:0000250
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11964411; 12373548; 12450740; 12496267; 12615048; 12763251; 12829630; 12914981; 12927199; 12946704; 14559369; 14608596; 14698681; 15040036; 15260493; 15464747; 15536283; 15561439; 15647484; 15890776; 16143427; 16274843; 16535834; 16837074; 16989746; 17157334; 17505309; 18297100; 18587446; 18776046; 19253017; 19656488; 19726710; 19896983; 20392936; 21093507; 21239630; 21270124; 21525858; 22813405; 23027805; 23785073; 24121132; 24309294; 24487953; 24564397; 24732637; 25117406; 25627687; 27534875; 27535680; 28466358; 28684275; 29339381; 31012948; 33422646; 6185005;
Motif
Gene Encoded By
Mass 12,841
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda