| IED ID | IndEnz0002000033 |
| Enzyme Type ID | protease000033 |
| Protein Name |
Cell growth regulator with EF hand domain protein 1 Cell growth regulatory gene 11 protein Hydrophobestin |
| Gene Name | Cgref1 Cgr11 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MSRWLMQMLMLPLLLLPLGQAAPKDGVARLDPEAQQQLTTNPFQPGPEQLRRLRDYLKGLEKMEEDPEQMNREQVLLYLFALHDFDQNGQLDGLELLSMLTAALAPGAAHFPINPVILVVDMVLETQDLDGDGLMTPAELINFPGEAPKRAESLPPALQEPQPAGSQPLLANSPLQSETQQSLGTKEEITSQVEAKRALEPEQEAGHHIETKVDALSPEGEARGQAESEGDAPGPREDAERQVESKDNEGEAKDLPAETLETQNTPNVVEAHSIQLENDEI |
| Enzyme Length | 281 |
| Uniprot Accession Number | P97586 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Mediates cell-cell adhesion in a calcium-dependent manner. Able to inhibit growth in several cell lines. {ECO:0000269|PubMed:19473726}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (4); Domain (2); Metal binding (9); Modified residue (2); Region (1); Signal peptide (1) |
| Keywords | Calcium;Cell adhesion;Cell cycle;Growth arrest;Metal-binding;Phosphoprotein;Reference proteome;Repeat;Secreted;Signal |
| Interact With | |
| Induction | INDUCTION: By p53. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19473726}. |
| Modified Residue | MOD_RES 217; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22673903; MOD_RES 228; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22673903 |
| Post Translational Modification | PTM: Probably digested extracellularly by an unknown serine protease generating extremely hydrophobic bioactive peptides. |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 30,835 |
| Kinetics | |
| Metal Binding | METAL 84; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 86; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 88; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 90; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 95; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 128; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 130; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 132; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 139; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448 |
| Rhea ID | |
| Cross Reference Brenda |