Detail Information for IndEnz0002000033
IED ID IndEnz0002000033
Enzyme Type ID protease000033
Protein Name Cell growth regulator with EF hand domain protein 1
Cell growth regulatory gene 11 protein
Hydrophobestin
Gene Name Cgref1 Cgr11
Organism Rattus norvegicus (Rat)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat)
Enzyme Sequence MSRWLMQMLMLPLLLLPLGQAAPKDGVARLDPEAQQQLTTNPFQPGPEQLRRLRDYLKGLEKMEEDPEQMNREQVLLYLFALHDFDQNGQLDGLELLSMLTAALAPGAAHFPINPVILVVDMVLETQDLDGDGLMTPAELINFPGEAPKRAESLPPALQEPQPAGSQPLLANSPLQSETQQSLGTKEEITSQVEAKRALEPEQEAGHHIETKVDALSPEGEARGQAESEGDAPGPREDAERQVESKDNEGEAKDLPAETLETQNTPNVVEAHSIQLENDEI
Enzyme Length 281
Uniprot Accession Number P97586
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Mediates cell-cell adhesion in a calcium-dependent manner. Able to inhibit growth in several cell lines. {ECO:0000269|PubMed:19473726}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Compositional bias (4); Domain (2); Metal binding (9); Modified residue (2); Region (1); Signal peptide (1)
Keywords Calcium;Cell adhesion;Cell cycle;Growth arrest;Metal-binding;Phosphoprotein;Reference proteome;Repeat;Secreted;Signal
Interact With
Induction INDUCTION: By p53.
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19473726}.
Modified Residue MOD_RES 217; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22673903; MOD_RES 228; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22673903
Post Translational Modification PTM: Probably digested extracellularly by an unknown serine protease generating extremely hydrophobic bioactive peptides.
Signal Peptide SIGNAL 1..21; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 30,835
Kinetics
Metal Binding METAL 84; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 86; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 88; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 90; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 95; /note=Calcium 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 128; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 130; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 132; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448; METAL 139; /note=Calcium 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448
Rhea ID
Cross Reference Brenda