| IED ID | IndEnz0002000045 |
| Enzyme Type ID | protease000045 |
| Protein Name |
Lon protease homolog, mitochondrial EC 3.4.21.53 |
| Gene Name | OsI_27415 |
| Organism | Oryza sativa subsp. indica (Rice) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae Liliopsida Petrosaviidae commelinids Poales Poaceae BOP clade Oryzoideae Oryzeae Oryzinae Oryza Oryza sativa (Rice) Oryza sativa subsp. indica (Rice) |
| Enzyme Sequence | MLRAAAAAAAVFPSRFAAAPAVAAVEEVRSPLLRVLGALRGGRVSTLGRRARFCSNSAGSDSEAAAAEAKAEDAVAAEGEADGKASSAIVPTVLRPEDCLSVIALPLPHRPLFPGFYMPIYVKDQKLLQALVENRKRSIPYAGAFLVKDEEGTDPNIVTSSDSDKSIDDLKGKELLQRLNEVGTLAQITSIQGDQVVLLGHRRLKITEMVQEDPLTVKVDHLKEKPYDKDDDVIKATSFEVISTLREVLKASSLWKDHVQTYTQHMGDFNYPRLADFGAAISGANKFLCQEVLEELDVYKRLKLTLELVKKEMEISKLQQSIAKAIEEKISGDQRRYLLNEQLKAIKKELGLETDDKTALSAKFRERIEAKKEKCPAHVLQVIEEELTKLQLLEASSSEFNVTRNYLDWLTVLPWGNYSDENFDVHHAQQILDEDHYGLSDVKERILEFIAVGKLRGTSQGKIICLSGPPGVGKTSIGRSIARALNRKFYRFSVGGLADVAEIKGHRRTYVGAMPGKMVQCLKSVGTANPLVLIDEIDKLGRGHSGDPASALLELLDPEQNVNFLDHYLDVPIDLSKVLFVCTANVIEMIPNPLLDRMEIIAIAGYITDEKMHIARDYLEKNTREACGIKPEQAEVTDAALLALIESYCREAGVRNLQKQIEKIYRKIALQLVRQGVSNEPTQEAAIVTASEEPNGGDSANKLKDETMEDPATENAAMTNADTASKEASELDLLKRTVDHDVHPAETPKEAVLTDSALSTDKLCTPEGNKDMEGAKEESADKAVEKVVIDSSNLGDYVGKPVFQAERIYEQTPVGVVMGLAWTAMGGSTLYIETTKVEEGDGKGALVLTGQLGDVMKESAQIAHTVGRAILLDKEPENLFFANSKVHLHVPAGSTPKDGPSAGCTMITSMLSLAMGKPVKKDLAMTGEVTLTGRILPIGGVKEKTIAARRSAVKTIVFPAANKRDFDELAPNVKEGLEVHFVDTYNEIFDIAFQSETQTETS |
| Enzyme Length | 1002 |
| Uniprot Accession Number | A2YQ56 |
| Absorption | |
| Active Site | ACT_SITE 901; /evidence=ECO:0000255|HAMAP-Rule:MF_03120; ACT_SITE 944; /evidence=ECO:0000255|HAMAP-Rule:MF_03120 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53; Evidence={ECO:0000255|HAMAP-Rule:MF_03120}; |
| DNA Binding | |
| EC Number | 3.4.21.53 |
| Enzyme Function | FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. {ECO:0000255|HAMAP-Rule:MF_03120}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 468..475; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_03120 |
| Features | Active site (2); Alternative sequence (1); Chain (1); Domain (2); Nucleotide binding (1); Sequence conflict (2) |
| Keywords | ATP-binding;Alternative splicing;DNA-binding;Hydrolase;Mitochondrion;Nucleotide-binding;Protease;Reference proteome;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03120}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 109,539 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |