IED ID | IndEnz0002000080 |
Enzyme Type ID | protease000080 |
Protein Name |
Phosphoglycerate kinase EC 2.7.2.3 |
Gene Name | pgk SPD_0445 |
Organism | Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) |
Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus pneumoniae Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) |
Enzyme Sequence | MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGGRAILFSHLGRVKEESDKAGKSLAPVAADLAAKLGQDVVFPGVTRGAELEAAINALEDGQVLLVENTRYEDVDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKALLEKANGKLILPVDSKEANAFAGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK |
Enzyme Length | 398 |
Uniprot Accession Number | Q04LZ5 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | BINDING 36; /note=Substrate; /evidence=ECO:0000255|HAMAP-Rule:MF_00145; BINDING 119; /note=Substrate; /evidence=ECO:0000255|HAMAP-Rule:MF_00145; BINDING 157; /note=Substrate; /evidence=ECO:0000255|HAMAP-Rule:MF_00145; BINDING 208; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_00145; BINDING 296; /note=ATP; via carbonyl oxygen; /evidence=ECO:0000255|HAMAP-Rule:MF_00145; BINDING 327; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_00145 |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP; Xref=Rhea:RHEA:14801, ChEBI:CHEBI:30616, ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216; EC=2.7.2.3; Evidence={ECO:0000255|HAMAP-Rule:MF_00145}; |
DNA Binding | |
EC Number | 2.7.2.3 |
Enzyme Function | |
Temperature Dependency | |
PH Dependency | |
Pathway | PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. {ECO:0000255|HAMAP-Rule:MF_00145}. |
nucleotide Binding | NP_BIND 354..357; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_00145 |
Features | Beta strand (16); Binding site (6); Chain (1); Helix (22); Nucleotide binding (1); Region (2); Turn (4) |
Keywords | 3D-structure;ATP-binding;Cytoplasm;Glycolysis;Kinase;Nucleotide-binding;Transferase |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00145}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | X-ray crystallography (1) |
Cross Reference PDB | 3ZLB; |
Mapped Pubmed ID | 24196407; |
Motif | |
Gene Encoded By | |
Mass | 41,939 |
Kinetics | |
Metal Binding | |
Rhea ID | RHEA:14801 |
Cross Reference Brenda |