Detail Information for IndEnz0002000085
IED ID IndEnz0002000085
Enzyme Type ID protease000085
Protein Name Pepsin A
EC 3.4.23.1
Fragment
Gene Name PGA
Organism Ursus thibetanus (Asiatic black bear) (Selenarctos thibetanus)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Carnivora Caniformia Ursidae (bears) Ursus Ursus thibetanus (Asiatic black bear) (Selenarctos thibetanus)
Enzyme Sequence FIIKVPLVKKKSLRKNLKEHGLLKDFLKKHSPNPASKYFPQEAAVMATQPLENYMDMEYF
Enzyme Length 60
Uniprot Accession Number P13636
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.; EC=3.4.23.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10094};
DNA Binding
EC Number 3.4.23.1
Enzyme Function FUNCTION: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Non-terminal residue (1); Propeptide (1)
Keywords Aspartyl protease;Digestion;Direct protein sequencing;Hydrolase;Protease;Secreted;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 7,052
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda