| IED ID | IndEnz0002000105 |
| Enzyme Type ID | protease000105 |
| Protein Name |
Peptidase B EC 3.4.11.23 Aminopeptidase B |
| Gene Name | pepB yfhI b2523 JW2507 |
| Organism | Escherichia coli (strain K12) |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Escherichia Escherichia coli Escherichia coli (strain K12) |
| Enzyme Sequence | MTEAMKITLSTQPADARWGEKATYSINNDGITLHLNGADDLGLIQRAARKIDGLGIKHVQLSGEGWDADRCWAFWQGYKAPKGTRKVVWPDLDDAQRQELDNRLMIIDWVRDTINAPAEELGPSQLAQRAVDLISNVAGDRVTYRITKGEDLREQGYMGLHTVGRGSERSPVLLALDYNPTGDKEAPVYACLVGKGITFDSGGYSIKQTAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLFLCCADNLISGNAFKLGDIITYRNGKKVEVMNTDAEGRLVLADGLIDASAQKPEMIIDAATLTGAAKTALGNDYHALFSFDDALAGRLLASAAQENEPFWRLPLAEFHRSQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYQQGWLHIDCSATYRKAPVEQWSAGATGLGVRTIANLLTA |
| Enzyme Length | 427 |
| Uniprot Accession Number | P37095 |
| Absorption | |
| Active Site | ACT_SITE 207; /evidence=ECO:0000255|HAMAP-Rule:MF_00504; ACT_SITE 281; /evidence=ECO:0000255|HAMAP-Rule:MF_00504 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln.; EC=3.4.11.23; Evidence={ECO:0000255|HAMAP-Rule:MF_00504}; |
| DNA Binding | |
| EC Number | 3.4.11.23 |
| Enzyme Function | FUNCTION: Probably plays an important role in intracellular peptide degradation (PubMed:20067529). {ECO:0000255|HAMAP-Rule:MF_00504, ECO:0000305|PubMed:20067529}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Beta strand (20); Chain (1); Helix (16); Metal binding (7); Sequence conflict (3); Turn (3) |
| Keywords | 3D-structure;Aminopeptidase;Cytoplasm;Hydrolase;Manganese;Metal-binding;Protease;Reference proteome |
| Interact With | P0A7C6 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00504}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 6OAD; 6OV8; |
| Mapped Pubmed ID | 15690043; 16606699; 16858726; 31282871; 31750992; 32306515; |
| Motif | |
| Gene Encoded By | |
| Mass | 46,180 |
| Kinetics | |
| Metal Binding | METAL 195; /note=Manganese 2; /evidence=ECO:0000255|HAMAP-Rule:MF_00504; METAL 200; /note=Manganese 1; /evidence=ECO:0000255|HAMAP-Rule:MF_00504; METAL 200; /note=Manganese 2; /evidence=ECO:0000255|HAMAP-Rule:MF_00504; METAL 218; /note=Manganese 2; /evidence=ECO:0000255|HAMAP-Rule:MF_00504; METAL 277; /note=Manganese 1; /evidence=ECO:0000255|HAMAP-Rule:MF_00504; METAL 279; /note=Manganese 1; /evidence=ECO:0000255|HAMAP-Rule:MF_00504; METAL 279; /note=Manganese 2; /evidence=ECO:0000255|HAMAP-Rule:MF_00504 |
| Rhea ID | |
| Cross Reference Brenda | 3.4.11.23; |