Detail Information for IndEnz0002000129
IED ID IndEnz0002000129
Enzyme Type ID protease000129
Protein Name Peptidase B
EC 3.4.11.23
Aminopeptidase B
Gene Name pepB SNSL254_A2735
Organism Salmonella newport (strain SL254)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Salmonella Salmonella enterica (Salmonella choleraesuis) Salmonella enterica I Salmonella newport Salmonella newport (strain SL254)
Enzyme Sequence MTEAMKITLSTQPADARWGDKATYSINNDGITLHLNGKDDLGLIQRAARKIDGLGIKQVALTGEGWDTERCWAFWAGYKGPKGVRTVMWPDLDDAQRQELDNRLTIIDWVRDTINAPAEELGPEQLAQRAVDLLCSVACDSVTYRITKGEDLREQNYMGLHTVGRGSERPPVLLALDYNPTGDKDAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLFLCCADNLISGNAFKLGDIIRYRNGKNVEVMNTDAEGRLVLADGLIDASAQHPQLIIDMATLTGAAKTALGNDYHALFSFDDTLAGRLLTSAAQENEPFWRLPLAEFHRNQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYREGWLHIDCSATYRKAPVEQWAAGATGLGVRTIANLLTA
Enzyme Length 427
Uniprot Accession Number B4T0R5
Absorption
Active Site ACT_SITE 207; /evidence=ECO:0000255|HAMAP-Rule:MF_00504; ACT_SITE 281; /evidence=ECO:0000255|HAMAP-Rule:MF_00504
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln.; EC=3.4.11.23; Evidence={ECO:0000255|HAMAP-Rule:MF_00504};
DNA Binding
EC Number 3.4.11.23
Enzyme Function FUNCTION: Probably plays an important role in intracellular peptide degradation. {ECO:0000255|HAMAP-Rule:MF_00504}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Chain (1); Metal binding (7)
Keywords Aminopeptidase;Cytoplasm;Hydrolase;Manganese;Metal-binding;Protease
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00504}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 46,355
Kinetics
Metal Binding METAL 195; /note=Manganese 2; /evidence=ECO:0000255|HAMAP-Rule:MF_00504; METAL 200; /note=Manganese 1; /evidence=ECO:0000255|HAMAP-Rule:MF_00504; METAL 200; /note=Manganese 2; /evidence=ECO:0000255|HAMAP-Rule:MF_00504; METAL 218; /note=Manganese 2; /evidence=ECO:0000255|HAMAP-Rule:MF_00504; METAL 277; /note=Manganese 1; /evidence=ECO:0000255|HAMAP-Rule:MF_00504; METAL 279; /note=Manganese 1; /evidence=ECO:0000255|HAMAP-Rule:MF_00504; METAL 279; /note=Manganese 2; /evidence=ECO:0000255|HAMAP-Rule:MF_00504
Rhea ID
Cross Reference Brenda