| IED ID | IndEnz0002000163 |
| Enzyme Type ID | protease000163 |
| Protein Name |
Gastricsin EC 3.4.23.3 Pepsinogen C |
| Gene Name | PGC |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA |
| Enzyme Length | 388 |
| Uniprot Accession Number | P20142 |
| Absorption | |
| Active Site | ACT_SITE 91; ACT_SITE 276 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.; EC=3.4.23.3; |
| DNA Binding | |
| EC Number | 3.4.23.3 |
| Enzyme Function | FUNCTION: Hydrolyzes a variety of proteins. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Alternative sequence (1); Beta strand (24); Chain (1); Disulfide bond (3); Domain (1); Erroneous initiation (1); Helix (16); Propeptide (1); Sequence conflict (2); Signal peptide (1); Turn (3) |
| Keywords | 3D-structure;Alternative splicing;Aspartyl protease;Digestion;Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Reference proteome;Secreted;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..16; /evidence="ECO:0000269|PubMed:2515193, ECO:0000269|PubMed:6816595" |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 1AVF; 1HTR; |
| Mapped Pubmed ID | 12128264; 12508350; 12698190; 12759353; 15200883; 15503827; 15688378; 16937501; 17288837; 17559360; 18256027; 18447628; 18844222; 19132389; 19173902; 19624876; 19731026; 20379614; 21303408; 22066020; 23047493; 23178618; 23311720; 23326145; 23455381; 24009139; 24284944; 24586594; 24895149; 25028655; 25551587; 25857852; 26158864; 26486507; 27865295; 29108629; 30155999; 30400679; 32228342; 32271765; 33127250; 34463892; 8098309; 9391244; 9794784; |
| Motif | |
| Gene Encoded By | |
| Mass | 42,426 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.23.3; |