| IED ID | IndEnz0002000165 |
| Enzyme Type ID | protease000165 |
| Protein Name |
Aminopeptidase C EC 3.4.22.40 Bleomycin hydrolase |
| Gene Name | pepC |
| Organism | Lactobacillus helveticus (Lactobacillus suntoryeus) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus helveticus (Lactobacillus suntoryeus) |
| Enzyme Sequence | MAKEINNDTIAKFENDLNNHPVFNVASHAAQENGIYKASQNLQTKIDLDPIFSIEIDTGKPADQKQSGRCWMFSALNTMRHPLQKKFKLQDFELSQNYTNFWDKFEKSNWFFENVIATADKDLGDRKVSFLFATPQQDGGQWDMLCGIIEKYGIVPKSVYPETANATNSSALNDTLNTLLRKDGLELRRLVNAGKSEDEVQARKEEMLNDVFRVLAISTCVPPKKFNFEYRDDNHNYHIDKDITPKEFFDKYVGMDLANHISTINAPTSDKPFHKVFSVEYLGNVEGGRQVRHLNLKVDEMKDLIIKQLNNGEVVWFGSNVVKDSERRAGLLATNLYRRDQLFDVDFSMSKADKLDSGESMMDHAMVITGVDIVDGKPTKWKIENSWGEKPGFKGYFVMSDSWFDSFVYQAVINKDILPEDLKKAYDEGKDNPIQLLPWDPMGALAFKY |
| Enzyme Length | 449 |
| Uniprot Accession Number | Q10744 |
| Absorption | |
| Active Site | ACT_SITE 70; /evidence=ECO:0000250; ACT_SITE 364; /evidence=ECO:0000250; ACT_SITE 385; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.; EC=3.4.22.40; |
| DNA Binding | |
| EC Number | 3.4.22.40 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Natural variant (6); Sequence conflict (2) |
| Keywords | Aminopeptidase;Cytoplasm;Hydrolase;Protease;Thiol protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 51,400 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |