| IED ID | IndEnz0002000170 |
| Enzyme Type ID | protease000170 |
| Protein Name |
Gastricsin EC 3.4.23.3 Pepsinogen C Fragment |
| Gene Name | PGC |
| Organism | Macaca fuscata fuscata (Japanese macaque) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Cercopithecoidea Cercopithecidae (Old World monkeys) Cercopithecinae Macaca (macaques) Macaca fuscata (Japanese macaque) Macaca fuscata fuscata (Japanese macaque) |
| Enzyme Sequence | QLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYHFGDLSVSYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPTLSVDGATTAMQGMVQEGALTSPIFSVYLSDQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPTLTFIINGVEFPLPPSSYILNNNGYCTVGVEPTYLSAQNSQPLWILGDVFLRSYYSVYDLSNNRVGFATAA |
| Enzyme Length | 377 |
| Uniprot Accession Number | P03955 |
| Absorption | |
| Active Site | ACT_SITE 80; ACT_SITE 265 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.; EC=3.4.23.3; |
| DNA Binding | |
| EC Number | 3.4.23.3 |
| Enzyme Function | FUNCTION: Hydrolyzes a variety of proteins. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (3); Domain (1); Non-terminal residue (1); Propeptide (2); Sequence conflict (2); Signal peptide (1) |
| Keywords | Aspartyl protease;Digestion;Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Secreted;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | PTM: Each pepsinogen is converted to corresponding pepsin at pH 2.0 in part as a result of the release of a 47 AA activation segment and in part as a result of stepwise proteolytic cleavage via an intermediate form(s). |
| Signal Peptide | SIGNAL <1..5; /evidence="ECO:0000269|PubMed:3514597, ECO:0000269|PubMed:3928607" |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 41,148 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |