| IED ID | IndEnz0002000178 |
| Enzyme Type ID | protease000178 |
| Protein Name |
Gastricsin EC 3.4.23.3 Pepsinogen C-1 |
| Gene Name | PGC PGNC |
| Organism | Suncus murinus (Asian house shrew) (Musk shrew) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Eulipotyphla (hedgehogs shrews moles and others) Soricidae (shrews) Crocidurinae Suncus (musk shrews) Suncus murinus (Asian house shrew) (Musk shrew) |
| Enzyme Sequence | MKWMVVALVCLQLLEAKVTKVTLKKFKSIRENLREQGLLEDFLKTNHYDPAQKYHFGDFSVAYEPMAYMDASYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTGHARFNPNQSSTYSTNGQTFSLQYGSGSLTGFFGYDTMTVQNIKVPHQEFGLSQNEPGTNFIYAQFDGIMGMAYPSLAMGGATTALQGMLQEGALTSPVFSFYLSNQQGSQNGGAVIFGGVDNSLYTGQIFWAPVTQELYWQIGVEEFLIGGQATGWCQQGCQAIVDTGTSLLTVPQQFMSALQQATGAQQDQYGQLAVNCNSIQSLPTLTFIINGVQFPLPPSAYVLNTNGYCFLGVEPTYLPSQNGQPLWILGDVFLRSYYSVYDMGNNRVGFATAA |
| Enzyme Length | 389 |
| Uniprot Accession Number | P81498 |
| Absorption | |
| Active Site | ACT_SITE 91; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094; ACT_SITE 277; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.; EC=3.4.23.3; |
| DNA Binding | |
| EC Number | 3.4.23.3 |
| Enzyme Function | FUNCTION: Hydrolyzes a variety of proteins. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (3); Domain (1); Propeptide (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Aspartyl protease;Digestion;Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Secreted;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..16; /evidence=ECO:0000269|PubMed:9354369 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 42,667 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |