| IED ID | IndEnz0002000193 |
| Enzyme Type ID | protease000193 |
| Protein Name |
Xaa-Pro dipeptidase X-Pro dipeptidase EC 3.4.13.9 Imidodipeptidase Peptidase D Proline dipeptidase Prolidase |
| Gene Name | pepd prd DDB_G0269382 |
| Organism | Dictyostelium discoideum (Slime mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold) |
| Enzyme Sequence | MSVHPRNQGKDDCCEKTHLDSQYSPGYYWLGNNTLKVPLVLHKENRQRLVSQILSKHKDQVKENSFILLESGKSTMQYDTDHEPLFKQERYFFWTFGSDIPDCFGIVGLDEQATSILCIPKLPAEYATWMGEIRSKEYYKSIFLVDQVLYVDEMMDYLKSKNASTIYTILGTNTDSGSTFVEPQYPGLRETFNVNNTLLFPEIAECRVIKSPKEVEVIRYCVDASVSAHKHVMRKVKVGLKEYQCESEFLHHVYNEWGCRNVGYTCICAANKNSAVLHYGHAGEPNSATISENGFCLFDMGAEYHSYTADITCSFPATGKFSPEQRVVYQAVLDASVAVMEAMRPGVSWVDMHKLAERCILAALLKAGILVGDLQDLIANKIGSVFFPHGLGHFLGLDTHDVGGYLGDCQPKVHSLRTTRTLKAGMVITSEPGCYFINHLLTQALSNPETAKFFNLTELDKYRNIGGVRIEDDILVTETGCDNLSKNLPRTIDEIEAFMLK |
| Enzyme Length | 501 |
| Uniprot Accession Number | Q55E60 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of Xaa-|-Pro dipeptides. Also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.; EC=3.4.13.9; |
| DNA Binding | |
| EC Number | 3.4.13.9 |
| Enzyme Function | FUNCTION: Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Metal binding (7) |
| Keywords | Dipeptidase;Direct protein sequencing;Hydrolase;Manganese;Metal-binding;Metalloprotease;Protease;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 20422638; 22120990; |
| Motif | |
| Gene Encoded By | |
| Mass | 56,426 |
| Kinetics | |
| Metal Binding | METAL 299; /note=Manganese 1; /evidence=ECO:0000250; METAL 310; /note=Manganese 1; /evidence=ECO:0000250; METAL 310; /note=Manganese 2; /evidence=ECO:0000250; METAL 393; /note=Manganese 2; /evidence=ECO:0000250; METAL 431; /note=Manganese 2; /evidence=ECO:0000250; METAL 471; /note=Manganese 1; /evidence=ECO:0000250; METAL 471; /note=Manganese 2; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |