| IED ID | IndEnz0002000233 |
| Enzyme Type ID | protease000233 |
| Protein Name |
Aminopeptidase E EC 3.4.22.- |
| Gene Name | pepE pepG |
| Organism | Lactobacillus helveticus (Lactobacillus suntoryeus) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus helveticus (Lactobacillus suntoryeus) |
| Enzyme Sequence | MAHELTVQELEKFSADFNKNPKNKVVARAAQRSGVLEASYNDRVQSELTRVFSTELDTDNVTNQKHSGRCWLFATLNVLRHEFGKKYKAKDFTFSQAYNFFWDKIERANMFYNRILDSADMPLDSRQVKTDLDFAGTDGGQFQMAAALVEKYGVVPSYAMPETFNTNDTTGFATALGDKLKKDALVLRKLKQEGKDDEIKKTREKFLSEVYQMTAIAVGEPPKKFDLEYRDDDKKYHLEKDLTPLEFLHKYLGGVDFDDYVVLTNAPDHEYDKLYGLPAEDNVSGSIRIKLLNVPMEYLTAASIAQLKDGEAVWFGNDVLRQMDRKTGYLDTNLYKLDDLFGVDLKMSKADRLKTGVGEVSHAMTLVGVDEDNGEVRQWKVENSWGDKSGAKGYYVMNNEWFNDYVYEVVVHKKYLTDKQKELAEGPITDLPAWDSLA |
| Enzyme Length | 438 |
| Uniprot Accession Number | P94870 |
| Absorption | |
| Active Site | ACT_SITE 70; /evidence=ECO:0000250; ACT_SITE 362; /evidence=ECO:0000250; ACT_SITE 383; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Can hydrolyze internal peptide bonds in Met-enkephalin and bradykinin; however, hydrolysis of alpha-, beta-, and kappa-caseins is not detected. |
| Temperature Dependency | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 32-37 degrees Celsius.; |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 4.5.; |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1) |
| Keywords | Aminopeptidase;Cytoplasm;Hydrolase;Protease;Thiol protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 50,022 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |