| IED ID | IndEnz0002000267 |
| Enzyme Type ID | protease000267 |
| Protein Name |
Alpha-aspartyl dipeptidase EC 3.4.13.21 Asp-specific dipeptidase Dipeptidase E |
| Gene Name | aad-a |
| Organism | Xenopus laevis (African clawed frog) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Xenopus Xenopus laevis (African clawed frog) |
| Enzyme Sequence | MMTMRRHLLLVSNSTLHGGGYLEHCQEHILKFLGAQVKRVLFIPYALHDRDAYAKTARQKFEALGYGLDSVHESPDPVDAVKKAEAIFIGGGNTFRLLKALYDNDLIAAIRKRVLEDGVPYIGSSAGTNVATISINTTNDMPIVYPPSLKALELVPFNINPHYLDPDGNSKHMGETREQRITQYHEEHDTPPVLGLREGCFLLVEGDKATLLGITRARLFLRGKNPTEHEPGHDFSFLLGHS |
| Enzyme Length | 242 |
| Uniprot Accession Number | Q91642 |
| Absorption | |
| Active Site | ACT_SITE 125; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 140; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 162; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.; EC=3.4.13.21; |
| DNA Binding | |
| EC Number | 3.4.13.21 |
| Enzyme Function | FUNCTION: Hydrolyzes dipeptides containing N-terminal aspartate residues. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1) |
| Keywords | 3D-structure;Cytoplasm;Dipeptidase;Hydrolase;Protease;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 7C9B; 7FFP; |
| Mapped Pubmed ID | 34431561; |
| Motif | |
| Gene Encoded By | |
| Mass | 26,952 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |