| IED ID | IndEnz0002000281 |
| Enzyme Type ID | protease000281 |
| Protein Name |
Neutral endopeptidase EC 3.4.24.- Endopeptidase O |
| Gene Name | pepO |
| Organism | Lactobacillus helveticus (Lactobacillus suntoryeus) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus helveticus (Lactobacillus suntoryeus) |
| Enzyme Sequence | MRRYLAVRGGAGDVAEPDLNAKPQDNLYLAVNSEWLSKAEIPADQTSAGVNTELDIKIEKRMMKDFADIASGKEKMPDIRDFDKAIALYKIAKNFDKRDAEKANPIQNDLQKILDLINFDKFKDNATELFMGPYALPFVFDVDADMKNTDFNVLHFGGPSTFLPDTTTYKTPEAKKLLDILEKQSINLLEMAGIGKEEARVYVQNALAFDQKLSKVVKSTEEWSDYAAIYNPVSLTEFLAKFKSFDMADFLKTILPEKVERVIVMEPRFLDHADELINPANFDEIKGWMLVKYINSVAKYLSQDFRAAAFPFNQAISGTPELPSQIKQAYRLANGAFDEAVGIFYGKKYFGEEAKHDVEDMIHNMLKVYEQRINDNNWLSEDTKKKAIIKLRALVLKIGYPEKIEKIYDLLQIDPERSLYENEAQMATVRTKYMLDKLTQPVDRSVWLMPGNLNNACYDPQRNDLTFPAGILQAPFYDIHQSRGANYGGIGATIGHEVSHAFDNSGAKFDEHGNMNNWWTDEDFAEFNKRVGQMVDIFDGLQYGPAKINGKQVVGENIADLAGLACAVQAGKNDNVDLKDLFENYARSWMQKQRPEAIKTEVQVDVHAPQPTRVNIPVQCQDDFYTAFDVKPDDGMWLDPEDRITIW |
| Enzyme Length | 647 |
| Uniprot Accession Number | O52071 |
| Absorption | |
| Active Site | ACT_SITE 497; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000255|PROSITE-ProRule:PRU10095"; ACT_SITE 560; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Domain (1); Metal binding (3) |
| Keywords | Hydrolase;Metal-binding;Metalloprotease;Protease;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 73,537 |
| Kinetics | |
| Metal Binding | METAL 496; /note="Zinc; catalytic"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000255|PROSITE-ProRule:PRU10095"; METAL 500; /note="Zinc; catalytic"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000255|PROSITE-ProRule:PRU10095"; METAL 556; /note="Zinc; catalytic"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233" |
| Rhea ID | |
| Cross Reference Brenda |