Detail Information for IndEnz0002000371
IED ID IndEnz0002000371
Enzyme Type ID protease000371
Protein Name Phosphatidylethanolamine-binding protein 1
PEBP-1
Basic cytosolic 21 kDa protein
HCNPpp

Cleaved into: Hippocampal cholinergic neurostimulating peptide
HCNP
Gene Name PEBP1 PBP PEBP
Organism Bos taurus (Bovine)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine)
Enzyme Sequence MPVDLSKWSGPLSLQEVDERPQHPLQVKYGGAEVDELGKVLTPTQVKNRPTSITWDGLDPGKLYTLVLTDPDAPSRKDPKYREWHHFLVVNMKGNNISSGTVLSDYVGSGPPKGTGLHRYVWLVYEQEGPLKCDEPILSNRSGDHRGKFKVASFRKKYELGAPVAGTCYQAEWDDYVPKLYEQLSGK
Enzyme Length 187
Uniprot Accession Number P13696
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). {ECO:0000250}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (10); Chain (1); Helix (5); Initiator methionine (1); Modified residue (6); Peptide (1); Region (2); Sequence conflict (1); Turn (1)
Keywords 3D-structure;ATP-binding;Cytoplasm;Direct protein sequencing;Disulfide bond;Lipid-binding;Nucleotide-binding;Phosphoprotein;Protease inhibitor;Reference proteome;Serine protease inhibitor
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm.
Modified Residue MOD_RES 6; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P30086; MOD_RES 13; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P31044; MOD_RES 42; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:P30086; MOD_RES 52; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P30086; MOD_RES 98; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P30086; MOD_RES 153; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P30086
Post Translational Modification
Signal Peptide
Structure 3D X-ray crystallography (2)
Cross Reference PDB 1A44; 1B7A;
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 20,986
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda