| IED ID |
IndEnz0002000417 |
| Enzyme Type ID |
protease000417 |
| Protein Name |
Plasminogen-binding protein PgbB
|
| Gene Name |
pgbB HP_0863 |
| Organism |
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
| Taxonomic Lineage |
cellular organisms
Bacteria
Proteobacteria
delta/epsilon subdivisions
Epsilonproteobacteria
Campylobacterales
Helicobacteraceae
Helicobacter
Helicobacter pylori (Campylobacter pylori)
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
|
| Enzyme Sequence |
MNKPFLILLIALIVFSGCNMRKYFKPAKHQIKGEAYFPNHLQESIVSSNRYGAILKNGAVIGDKGLTQLRIGKNFNYESSFLNESQGFFILAQDCLNKIDKKTNKSKVAKTEETELKLKGVEAEVQDKVCHQVELISNNPNASQQSIVIPLETFALSASVKGNLLAVVLADNSANLYDITSQKLLFSEKGSPSTTINSLMAMPIFMDTVVVFPMLDGRLLVVDYVHGNPTPIRNIVISSDKFFNNITYLIVDGNNMIASTGKRILSVVSGQEFNYDGDIVDLLYDKGTLYVLTLDGQILQMDKSLRELNSVKLPSSLNTIVLNHNKLYSLEKRGYVIEVDLNDFDSYNVYKTPTIGSFKFFSSNRLDKGVFYDKNRVYYDRYYLDYNDFKPKLYPVVEKSASKKSQKGEKGNAPIYLQERHKAKENKQPLEENKVKPRNSGFEEEEVKTRRPEPIRDQNNATQQGETKNNESKNAPVLKENAAKKEVPKPNSKEEKRRLKEEKKKAKAEQRAREFEQRAREHQERDEKELEERRKALEMNKK |
| Enzyme Length |
542 |
| Uniprot Accession Number |
O25534 |
| Absorption |
|
| Active Site |
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| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
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| Enzyme Function |
FUNCTION: Binds plasminogen, specifically, and in a concentration and lysine-dependent manner. Plasminogen is the precursor of plasmin, a serine protease that cleaves fibrin, fibronectin, laminin and vitronectin. Acquisition of plasminogen/plasmin could enable H.pylori to degrade host components. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (3); Region (1) |
| Keywords |
Reference proteome |
| Interact With |
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| Induction |
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| Subcellular Location |
SUBCELLULAR LOCATION: Cell surface {ECO:0000305}. Note=The plasminogen-binding region is localized on the surface the bacterium. {ECO:0000305}. |
| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
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| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
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| Gene Encoded By |
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| Mass |
61,900 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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