| IED ID | IndEnz0002000421 |
| Enzyme Type ID | protease000421 |
| Protein Name |
Aminopeptidase PepS EC 3.4.11.- |
| Gene Name | pepS |
| Organism | Streptococcus thermophilus |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus thermophilus |
| Enzyme Sequence | MVLPNFKENLEKYAKLLVTNGINVQPGHTVALSIDVEQAELAHLLVKEAYALGAAEVIVQWSDDTINRERFLHAEMNRIEEVPAYKKAEMEYLLEKKASRLGVRSSDPDAFNGVAPERLSAHAKAIGAAFKPMQVATQSNKVSWTVAAAAGKEWAKKVFPNASSDEEAVDLLWNQIFKTCRVYEKDPVRAWKEHADRLDAKARILNEAQFSALHYTAPGTDLTLGLPKNHVWESAGAINAQGESFLPNMPTEEVFTAPDFRRAYGYVSSTKPLSYNGNIIEGIKVTFKDGEIVDITADQGEKVMKNLVFNNNGARALGECALVPDSSPISQSGITFFNTLFDENASNHLAIGAAYATSVEGGADMTEEELKAAGLNRSDVHVDFIIGSNQMNIDGIHHDGSRVPIFRNGDWVI |
| Enzyme Length | 413 |
| Uniprot Accession Number | Q9X4A7 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.11.- |
| Enzyme Function | FUNCTION: Exhibits a high specificity towards peptides possessing arginine or aromatic amino acids at the N-terminus. Could be involved both in bacterial growth by supplying amino acids. {ECO:0000269|PubMed:10406960}. |
| Temperature Dependency | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 55 degrees Celsius. {ECO:0000269|PubMed:10406960}; |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.5-8.5. {ECO:0000269|PubMed:10406960}; |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Metal binding (8) |
| Keywords | Aminopeptidase;Direct protein sequencing;Hydrolase;Metal-binding;Metalloprotease;Protease |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 45,318 |
| Kinetics | |
| Metal Binding | METAL 253; /note=Divalent metal cation 1; /evidence=ECO:0000250|UniProtKB:P42778; METAL 319; /note=Divalent metal cation 1; /evidence=ECO:0000250|UniProtKB:P42778; METAL 319; /note=Divalent metal cation 2; /evidence=ECO:0000250|UniProtKB:P42778; METAL 343; /note=Divalent metal cation 1; /evidence=ECO:0000250|UniProtKB:P42778; METAL 343; /note=Divalent metal cation 2; /evidence=ECO:0000250|UniProtKB:P42778; METAL 348; /note=Divalent metal cation 1; /evidence=ECO:0000250|UniProtKB:P42778; METAL 381; /note=Divalent metal cation 2; /evidence=ECO:0000250|UniProtKB:P42778; METAL 383; /note=Divalent metal cation 2; /evidence=ECO:0000250|UniProtKB:P42778 |
| Rhea ID | |
| Cross Reference Brenda |