| IED ID | IndEnz0002000476 |
| Enzyme Type ID | protease000476 |
| Protein Name |
Pigment epithelium-derived factor PEDF Caspin Serpin F1 Stromal cell-derived factor 3 SDF-3 |
| Gene Name | Serpinf1 Pedf Sdf3 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MQALVLLLWTGALLGHGSSQNVPSSSEGSPVPDSTGEPVEEEDPFFKVPVNKLAAAVSNFGYDLYRLRSSASPTGNVLLSPLSVATALSALSLGAEHRTESVIHRALYYDLITNPDIHSTYKELLASVTAPEKNLKSASRIVFERKLRVKSSFVAPLEKSYGTRPRILTGNPRVDLQEINNWVQAQMKGKIARSTREMPSALSILLLGVAYFKGQWVTKFDSRKTTLQDFHLDEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTGSMSIIFFLPLTVTQNLTMIEESLTSEFIHDIDRELKTIQAVLTVPKLKLSFEGELTKSLQDMKLQSLFESPDFSKITGKPVKLTQVEHRAAFEWNEEGAGSSPSPGLQPVRLTFPLDYHLNQPFLFVLRDTDTGALLFIGRILDPSST |
| Enzyme Length | 417 |
| Uniprot Accession Number | P97298 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. {ECO:0000269|PubMed:12632345}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (17); Chain (1); Compositional bias (1); Glycosylation (1); Helix (14); Modified residue (2); Region (1); Sequence conflict (5); Signal peptide (1); Turn (6) |
| Keywords | 3D-structure;Direct protein sequencing;Glycoprotein;Phosphoprotein;Pyrrolidone carboxylic acid;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. Melanosome {ECO:0000250}. |
| Modified Residue | MOD_RES 20; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000250|UniProtKB:P36955; MOD_RES 24; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P36955 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000250 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 6LOS; |
| Mapped Pubmed ID | 11180952; 11217851; 12072560; 12239160; 12447163; 12466851; 12641447; 12740569; 12912908; 12941042; 14681479; 15020256; 15051476; 15549636; 15713745; 16602821; 16839360; 17692294; 18180304; 18191271; 18348263; 18602915; 19115638; 19661223; 19898467; 20185831; 20709803; 21236558; 21267068; 21386905; 21576363; 21652703; 21677750; 21846721; 21964188; 22171010; 22234980; 22410737; 22933798; 23075882; 23108227; 23295464; 23413146; 23600479; 23646899; 23748041; 23850519; 23884140; 23887690; 24006456; 24194600; 24318110; 24456163; 24583261; 24664775; 24760990; 25003563; 25054647; 25095732; 25368097; 25562624; 25636741; 25700221; 26693895; 26700654; 27127101; 27440994; 27557659; 28190640; 28569772; 28706437; 28747334; 28860613; 28911166; 28972155; 29075761; 29259049; 29294343; 29351407; 29438518; 29449449; 29736859; 29752430; 30042381; 30160348; 30414426; 30786278; 31028961; 31117965; 31661672; 31676463; 31711388; 31968655; 32377760; 32385162; 32427349; 33008127; 33412338; 33498962; 34774969; 7814443; |
| Motif | |
| Gene Encoded By | |
| Mass | 46,234 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |