| IED ID | IndEnz0002000527 |
| Enzyme Type ID | protease000527 |
| Protein Name |
Pyrrolidone-carboxylate peptidase EC 3.4.19.3 5-oxoprolyl-peptidase Pyroglutamyl-peptidase I PGP-I Pyrase |
| Gene Name | pcp DR_0490 |
| Organism | Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Deinococcus-Thermus Deinococci Deinococcales Deinococcaceae Deinococcus Deinococcus radiodurans Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) |
| Enzyme Sequence | MPTLLLTGFEPFHTHPDNPSAQAAQELHGLELPGGWGVHSALLPVEPHAAGAALTRLLSEQDPGAVLLTGLAAGRPQVTLERVGVGVMDFQIPDNAGQTYRDQPIEPDAPAAYLATLPLRAILAAWREAEIPGDISNSAGLYVCNFVLYHALHWLREHGRGAVPCGFLHVPANAAVALAVPADRPPLPYLPQSEITRAVRVAAEAITAQSSVLQMGKM |
| Enzyme Length | 218 |
| Uniprot Accession Number | Q9RX25 |
| Absorption | |
| Active Site | ACT_SITE 81; /evidence=ECO:0000250; ACT_SITE 144; /evidence=ECO:0000250; ACT_SITE 169; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.; EC=3.4.19.3; |
| DNA Binding | |
| EC Number | 3.4.19.3 |
| Enzyme Function | FUNCTION: Removes 5-oxoproline from various penultimate amino acid residues except L-proline. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (9); Chain (1); Helix (7) |
| Keywords | 3D-structure;Cytoplasm;Hydrolase;Protease;Reference proteome;Thiol protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (3) |
| Cross Reference PDB | 5Z40; 5Z47; 5Z48; |
| Mapped Pubmed ID | 30950401; |
| Motif | |
| Gene Encoded By | |
| Mass | 23,096 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |