Detail Information for IndEnz0002000540
IED ID IndEnz0002000540
Enzyme Type ID protease000540
Protein Name Aspartic protease pepA
EC 3.4.23.-
Gene Name MCYG_00144
Organism Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Microsporum Arthroderma otae (Microsporum canis) Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Enzyme Sequence MVLINQLGAVLAVCATLTVAAPTKGKARFNVPQVAIPKKMVHHPAVSYARALHKFGMKVPKTVQDAAKGSVPTTPTPSDEQYVTQVTVGEGKLNLDLDTGSGDLQGHNLYKPTSNSKRLNGYSWQISYGDMSSAGGDVFLDTVSIGDVTASSQAVESAKKVSDQFAKDKATDGLMGLSFSVLNTVQPKPQTTFLDTVLSQLEKPLFTCTLKHGEPGSYDFGYIDDAKHSGEITYTQVDNSEGWWGFTADSYSIGGPNTTSFRGDSSGMANGGSISGIADTGTTLMLLSDDVVGEYYGQVQGATNDQQQGGYIFPCDAQLPDFTLSIGGYNAVVPGKFMNYQEIDGSMCFGGLQSSGSSGGPNIFGDVFLKSQFVVWDTQGPRIGFAPQA
Enzyme Length 389
Uniprot Accession Number C5FBS2
Absorption
Active Site ACT_SITE 98; /evidence=ECO:0000255|PROSITE-ProRule:PRU01103; ACT_SITE 279; /evidence=ECO:0000255|PROSITE-ProRule:PRU01103
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.23.-
Enzyme Function FUNCTION: Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions. {ECO:0000250|UniProtKB:Q12567}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Chain (1); Disulfide bond (1); Domain (1); Glycosylation (1); Propeptide (1); Signal peptide (1)
Keywords Aspartyl protease;Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Secreted;Signal;Virulence;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q12567}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..20; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 41,167
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda