Detail Information for IndEnz0002000631
IED ID IndEnz0002000631
Enzyme Type ID protease000631
Protein Name Pyrrolidone-carboxylate peptidase
EC 3.4.19.3
5-oxoprolyl-peptidase
Pyroglutamyl-peptidase I
PGP-I
Pyrase
Gene Name pcp PF1299
Organism Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic Lineage cellular organisms Archaea Euryarchaeota Thermococci Thermococcales Thermococcaceae Pyrococcus Pyrococcus furiosus Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Enzyme Sequence MKVLVTGFEPFGGEKINPTERIAKDLDGIKIGDAQVFGRVLPVVFGKAKEVLEKTLEEIKPDIAIHVGLAPGRSAISIERIAVNAIDARIPDNEGKKIEDEPIVPGAPTAYFSTLPIKKIMKKLHERGIPAYISNSAGLYLCNYVMYLSLHHSATKGYPKMSGFIHVPYIPEQIIDKIGKGQVPPSMCYEMELEAVKVAIEVALEELL
Enzyme Length 208
Uniprot Accession Number O73944
Absorption
Active Site ACT_SITE 79; ACT_SITE 142; ACT_SITE 166
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.; EC=3.4.19.3;
DNA Binding
EC Number 3.4.19.3
Enzyme Function FUNCTION: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Beta strand (9); Chain (1); Disulfide bond (1); Helix (7)
Keywords 3D-structure;Cytoplasm;Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Reference proteome;Thiol protease
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D X-ray crystallography (9)
Cross Reference PDB 1IOF; 1IOI; 1X10; 1X12; 1Z8T; 1Z8W; 1Z8X; 2DF5; 2EO8;
Mapped Pubmed ID 16752900; 17510955;
Motif
Gene Encoded By
Mass 22,822
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda 3.4.19.3;