| IED ID | IndEnz0002000710 |
| Enzyme Type ID | protease000710 |
| Protein Name |
Pyrrolidone-carboxylate peptidase EC 3.4.19.3 5-oxoprolyl-peptidase Pyroglutamyl-peptidase I PGP-I Pyrase |
| Gene Name | pcp LS215_1148 |
| Organism | Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) |
| Taxonomic Lineage | cellular organisms Archaea TACK group Crenarchaeota Thermoprotei Sulfolobales Sulfolobaceae Sulfolobus Sulfolobus islandicus Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) |
| Enzyme Sequence | MTVLLFGFEPFLEYKENPSQLIVEALNGSTILKEEVKGVILPVEYEKIEDLIVTKIREMKPILTLGIGVAPGRAKITPEKIAINYKYSREGDNAGKKYKGEKIDPLGQDGIFTNIPVEDLVDLLNENGIPAELSLSAGSYLCNNAMYIIIREARKYNSLGGFIHVPLHESYAARIQRPIPSMSLDTMIRGIRLSMEFILTNKKENLTFS |
| Enzyme Length | 209 |
| Uniprot Accession Number | C3MP49 |
| Absorption | |
| Active Site | ACT_SITE 79; /evidence=ECO:0000255|HAMAP-Rule:MF_00417; ACT_SITE 142; /evidence=ECO:0000255|HAMAP-Rule:MF_00417; ACT_SITE 164; /evidence=ECO:0000255|HAMAP-Rule:MF_00417 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.; EC=3.4.19.3; Evidence={ECO:0000255|HAMAP-Rule:MF_00417}; |
| DNA Binding | |
| EC Number | 3.4.19.3 |
| Enzyme Function | FUNCTION: Removes 5-oxoproline from various penultimate amino acid residues except L-proline. {ECO:0000255|HAMAP-Rule:MF_00417}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1) |
| Keywords | Cytoplasm;Hydrolase;Protease;Thiol protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00417}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 23,404 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |