| IED ID | IndEnz0002000782 |
| Enzyme Type ID | protease000782 |
| Protein Name |
Proprotein convertase subtilisin/kexin type 5 EC 3.4.21.- Proprotein convertase PC6-like aPC6 |
| Gene Name | PC6 |
| Organism | Branchiostoma californiense (California lancelet) (Amphioxus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Cephalochordata Leptocardii Amphioxiformes Branchiostomidae Branchiostoma Branchiostoma californiense (California lancelet) (Amphioxus) |
| Enzyme Sequence | MPPAIVILALFTAALCAVNLRTVAADGPRIYRNEWALHVEGGTAAADRLASKHGFINKGQIGSLEDHYLFVHRRTWKRSLRSSSHRHALLQREPEVRWLQQQVVKRRVKRRVKRVYSMYPWEQRVQHSSPQVNNPAQQDNLWDPHFNDEKWDKMWYLHCDRPEFACQWSDMNVEAAWKKGYTGKGVVVSILDDGSETDHPDLAGNYDPDASSDINGGTLDPTPRYEYTNENRHGTRCAGEVAAMGNNSFCSVGVAYKASIGGVRMLDGDVTDSVEAASLGLNPQHIMIYSASWGPDDDGKTVDGPANLAQKTFQAGAENGRDKLGSIFVWASGNGGRTHDSCGCDGYTNSIYTISVSSASEQGKVPWYLEPCASTLATTYSSGAPHERKVITTDLRKGCTESHTGTSASAPMAAGILALALEANPMLTWRDMQYIVVMAANPSPLDRDTESAYPRDPRKESDFVTNGAGLRVSHNFGFGLMDAGKMVELAESWRRVPEQHVCEEDPNAQQRAITKGETIVDTKTTGGCNGTDHHVKYLEHVVVEISLDHPCRGHLSIHITSPSGTRSTLLPERQFDSSSDGLKDWAFMTTHCWGEQPEGDWILEVKDLGQQNCQRYGLRTVLPVLRKWKLILYGTAEHPLYKRDEESRPHTPQTREEPTDEEECEDGDYYDRSKQRCRHCHDSCATCHGRHSGQCLSCHEGNYFVEDEGTCSEECGQGYYKDEEERKCLDCSADCLTCQVSADHCTSCDDEDGLKLFENTCVAQCSEGRYMDENDVCQDCDDSCDTCTGPDATDCVTCADEDLLQESQCVESCSSGYFQQEYECLKCHATCASCSGSRDDQCLTCSGHLELDEDTHRCITSCEDGEYGTEEGKCEDCNIICKKCNGSQADQCLECHHDTNLYDTTCVQYCGNRRYPENGECHPCHPSCLGCIGGEINQCNQCITDYEGEDHFLYQGTCHVTCPPGLYGDTTDQVCKACAPGCIACDGPADNQCTLCEEERAPTDGRCQSEGSQTDEAECAEGCHSCEEGPDICDSCDEDYYLTEDTCVRRTNCPSFTYPDDQDRECRPCHDNCEACDGPNNQNCNSCKEGFYKTPDGCSTGCPNRYYKDDTNKECKPCDSSCFTCSGPASFHCLSCADGDFLHESSCRSTCPAGFIGNAESHECVESSCEQDQYYSSETGRCEDCPYNCRACDNDGDCAECAPTYIVVDGRCRPEETCEDGEYQDRDRDTAELSCRPCHQSCKTCSGPSDTDCDSCKGDDTILDRGECITSCGPGEYMDRREKKCKACHPTCKECSDEYDDTCTACNDGFLLTDASSCEAGCPPGQFLHHGDCDSCHRECKTCDGPHHDNCLSCQPGSYLNDQQCSTHCPEGTFEETYEDDSGETVLQCRLCHVNCKTCHGEGEEDCMECANDIKYKQDGRCVTECQEGHYPDLTNECQQCWSDCETCDGPRNDQCVTCPYNYYLVLGKCLEDCPEGYYDTMRQEKECGECHPSCATCNEGGNYNCLSCPYGSKLGEGVCYPMCEEHEYYVEKTQICEECDNSCKTCRGSTAHDCLSCEAPYGYHAMKHLCTACCEEGSPENEYCCICHESTRLCITDREAEGVQFSSADSIPTNVAYIAVATFICVVIVVLFFVVFGMLQARSNGRLCWAHKYQQVPTTRYEKMNDHVNILSQEDFYNEDSLSEDEIHSIDSTRH |
| Enzyme Length | 1696 |
| Uniprot Accession Number | Q9NJ15 |
| Absorption | |
| Active Site | ACT_SITE 192; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 233; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 407; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (4); Chain (1); Compositional bias (1); Domain (2); Glycosylation (3); Propeptide (1); Region (3); Signal peptide (1); Site (1); Topological domain (2); Transmembrane (1) |
| Keywords | Alternative splicing;Cell membrane;Cleavage on pair of basic residues;Glycoprotein;Hydrolase;Membrane;Protease;Repeat;Secreted;Serine protease;Signal;Transmembrane;Transmembrane helix;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Isoform A]: Secreted.; SUBCELLULAR LOCATION: [Isoform C]: Secreted.; SUBCELLULAR LOCATION: [Isoform B]: Cell membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 188,411 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |