Detail Information for IndEnz0002000783
IED ID IndEnz0002000783
Enzyme Type ID protease000783
Protein Name Proprotein convertase subtilisin/kexin type 5
EC 3.4.21.-
Proprotein convertase 5
PC5
Proprotein convertase 6
PC6
hPC6
Subtilisin/kexin-like protease PC5
Gene Name PCSK5 PC5 PC6
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDGEYVDEHGHCQTCEASCAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTSCGADNYGREHFLYQGECGDSCPEGHYATEGNTCLPCPDNCELCHSVHVCTRCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYRFDHHCYKTCPEKTYSEEVECKACDSNCGSCDQNGCYWCEEGFFLLGGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKETKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECCDCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAGYEKLADPNKSYSSYKSSYRESTSFEEDQVIEYRDRDYDEDDDDDIVYMGQDGTVYRKFKYGLLDDDDIDELEYDDESYSYYQ
Enzyme Length 1860
Uniprot Accession Number Q92824
Absorption
Active Site ACT_SITE 171; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 212; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 386; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.21.-
Enzyme Function FUNCTION: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. {ECO:0000269|PubMed:19764806, ECO:0000269|PubMed:20555025, ECO:0000269|PubMed:22740495}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Alternative sequence (2); Chain (1); Domain (3); Glycosylation (12); Motif (1); Propeptide (1); Region (3); Repeat (22); Sequence conflict (6); Signal peptide (1); Site (1); Topological domain (2); Transmembrane (1)
Keywords Alternative splicing;Cleavage on pair of basic residues;Glycoprotein;Hydrolase;Membrane;Pregnancy;Protease;Reference proteome;Repeat;Secreted;Serine protease;Signal;Transmembrane;Transmembrane helix;Zymogen
Interact With O76003; P60409; P60410; Q9BQ66; P26371; Q5T5A8; P50222; Q7Z3S9; Q7Z417; O75716; Q6UY14-3; Q8WW18; Q6P5X5; Q02930-3; A8MQ03; Q8NFT6-2; Q92608; Q9NVL1-2; O95363; O43559; Q96NT3-2; P49639; P17482; Q0VD86; Q07627; P60410; P60411; Q8IUC1; P59991; Q3SY46; Q3LHN2; Q9BYR8; Q9BYR7; P26371; Q5T752; Q5T754; Q5TA81; Q5T5A8; Q9BYE3; Q99750; Q6FHY5; P0DPK4; Q6NSM0; Q92570; Q7Z417; P32242; P29122; Q9NRQ2; Q12837; Q9NUL5-4; P49901; O43609; Q8WW24; Q08117-2; Q9BUZ4; Q96RU7; Q8IWZ5; Q15645; Q70EL1-9; A8MV65-2; Q8IVP9; Q8N720; Q96EG3
Induction
Subcellular Location SUBCELLULAR LOCATION: [Isoform PC6A]: Secreted. Note=Secreted through the regulated secretory pathway. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform PC6B]: Endomembrane system; Single-pass type I membrane protein. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes. {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..32; /evidence=ECO:0000250
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11723118; 15522936; 15601911; 15911696; 16189514; 16713569; 16912035; 17088546; 17242158; 18039650; 18096669; 18245819; 18519639; 19913121; 20031622; 20379614; 20628086; 21078624; 21094132; 21273245; 21700711; 21971156; 23088713; 23686857; 25350918; 25416956; 25429785; 26055999; 28468828; 29126984; 8615794;
Motif MOTIF 519..521; /note=Cell attachment site; /evidence=ECO:0000255
Gene Encoded By
Mass 206,942
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda 3.4.21.B26;