Detail Information for IndEnz0002000785
IED ID IndEnz0002000785
Enzyme Type ID protease000785
Protein Name Proprotein convertase subtilisin/kexin type 5
EC 3.4.21.-
Proprotein convertase 5
PC5
Proprotein convertase 6
PC6
Subtilisin/kexin-like protease PC5
rPC5
Gene Name Pcsk5
Organism Rattus norvegicus (Rat)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat)
Enzyme Sequence MDWGWGSRCCRPGRRDLLCVLALLAGCLLPVCRTRVYTNHWAVKIAGGFAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDLSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGAEDYAGPCDPECSEVGCDGPGPDHCTDCLHYHYKLKNNTRICVSSCPPGHFHADKKRCRKCAPNCESCFGSHADQCLSCKYGYFLNEETSSCVAQCPEGSYQDIKKNICGKCSENCKTCTGFHNCTECKGGLSLQGSRCSVTCEDGQFFSGHDCQPCHRFCATCAGAGADGCINCTEGYVMEEGRCVQSCSVSYYLDHSLEGGYKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGMCQMGAICKDGEYIDEQGHCQICDASCAKCWGPTQDDCISCPITRVFDDGRCVMNCPSWKFELKKQCHPCHHTCQGCQGSGPSNCTSCKAGEFQDSEYGECMPCEEGCVGCTVDDPGACTSCATGYYMFERHCYKACPEKTFGEKWECKACGTNCGSCDQHECYWCEEGFFLSSGSCVQDCDPGFYGDQELGECKPCHRACETCTGLGYNQCSSCPEGLQLWHGTCIWPTWPHVEGKVWNEAVPTEKPSLVRSLPQDRRKWKVQIKRDATRQYQPCHSSCKTCNGSLCTSCPAGTYLWLQACVPSCPQGTWLSVRSSSCEKCAEGCASCSGDDLCQRCLSQPSNTLLLHEGRCYHSCPEGFYAKDGVCEHCSSPCKTCKGNATSCHSCEGDFVLDHGVCWETCPEKHVAVEGVCKHCPERCQDCIHEKTCKECMPDFFLYNDMCHHSCPKNFYPDMRQCVPCHKNCLGCNGPKEDDCKACADTSKVLHNGLCLDECPKGTYKDEVNDECRDCPESCLICSSAWTCLTCREGFTVVQDVCTAPKECAAIEYWDVGSHRCQPCHRKCSRCSGPSENQCYTCPRETFLLNTTCVKECPEGYHTDKDSHQCVPCHSSCRTCEGPHSMQCLSCRPGWFQLGKECLLQCRDGYYGESTSGRCEKCDKSCKTCRGPQPTDCQSCDTFFFLLRSKGQCHLACPEHYYADQHAQTCERCHPTCDKCSGKEAWNCLSCVWSYHLLKGICTPECIVGEYRDGKGENFNCKKCHESCMECKGPGSKNCTGCSAGLLLQMDDSRCLRCCNASHPHRSQDCCDCQSSTDECILPASDDTVFHEHTKTALLVTSGAMLLLLLGAAVVVWRKSRSQPVAKGRYEKLAEPTVSYSSYRSSYLDEDQVIEYRDRDYDEDDEDDIVYMGQDGTVYRKFKYGLLDEAEDDELEYDDESYSYQ
Enzyme Length 1809
Uniprot Accession Number P41413
Absorption
Active Site ACT_SITE 173; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 214; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 388; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.21.-
Enzyme Function FUNCTION: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Alternative sequence (2); Chain (1); Domain (2); Glycosylation (8); Motif (1); Propeptide (1); Region (3); Repeat (21); Signal peptide (1); Site (1); Topological domain (2); Transmembrane (1)
Keywords Alternative splicing;Cleavage on pair of basic residues;Glycoprotein;Hydrolase;Membrane;Pregnancy;Protease;Reference proteome;Repeat;Secreted;Serine protease;Signal;Transmembrane;Transmembrane helix;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: [Isoform PC5A]: Secreted {ECO:0000250}. Note=Secreted through the regulated secretory pathway. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform PC5B]: Endomembrane system {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes. {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..34; /evidence=ECO:0000250
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10408612; 10906713; 11181735; 11882580; 12649739; 14608596; 14970114; 15358140; 18502031; 21700711; 23686857; 28975535; 33313955; 9729404;
Motif MOTIF 521..523; /note=Cell attachment site; /evidence=ECO:0000255
Gene Encoded By
Mass 201,308
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda 3.4.21.B26;