Detail Information for IndEnz0002000790
IED ID IndEnz0002000790
Enzyme Type ID protease000790
Protein Name Proprotein convertase subtilisin/kexin type 7
EC 3.4.21.-
Prohormone convertase 7
Proprotein convertase 7
PC7
rPC7
Subtilisin/kexin-like protease PC7
Gene Name Pcsk7 Pc7
Organism Rattus norvegicus (Rat)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat)
Enzyme Sequence MPKGRQKVPRLDARLGLPICLCLELAIFFLVPQVMGLTEAGGLDTLGAGGLSWAVHLDSLEGERKEESLIQQANAVAQAAGLVNAGRIGELQGHYLFVQPAGHGQAMEAEAMRQQAEAVLAKHEAVRWHSEQRLLKRAKRSIHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTVQDIAPNYSPEGSYDLNSNDPDPMPHPDEENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVMAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATQYEDHRADWLTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPMLKENKAVPRSPHSLEVLWNVSRTDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGVYRLVIRDVGDEPLQVGILQQWQLTLYGSTWSPVDIKDRQSLLESAMSGKYLHDDFTLPCPPGLKIPEEDGYSITPNTLKTLVLVGCFSVFWTIYYMLEVCLSQRSKASTHGCRRGCCPWPPQSQNSKEVGTALESMPLCSSKDLDGVDSEHGDCTTASSLLAPELLGEADWSLSQNSKSDLDCPPHQPPDLKDGQIC
Enzyme Length 783
Uniprot Accession Number Q62849
Absorption
Active Site ACT_SITE 186; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 227; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 405; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240
Activity Regulation ACTIVITY REGULATION: Inhibited by zinc and copper.
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.21.-
Enzyme Function FUNCTION: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Compositional bias (1); Domain (2); Glycosylation (4); Propeptide (1); Region (2); Signal peptide (1); Site (1); Topological domain (2); Transmembrane (1)
Keywords Cleavage on pair of basic residues;Direct protein sequencing;Glycoprotein;Golgi apparatus;Hydrolase;Membrane;Protease;Reference proteome;Serine protease;Signal;Transmembrane;Transmembrane helix;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Seems to be localized intracellularly to the trans Golgi network.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..36
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 85,599
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda 3.4.21.B27;