| IED ID | IndEnz0002000807 |
| Enzyme Type ID | protease000807 |
| Protein Name |
Procollagen C-endopeptidase enhancer 1 Procollagen COOH-terminal proteinase enhancer 1 PCPE-1 Procollagen C-proteinase enhancer 1 Type 1 procollagen C-proteinase enhancer protein Type I procollagen COOH-terminal proteinase enhancer |
| Gene Name | PCOLCE PCPE1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPKSQPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPGEGLAVTVSLIGAYKTGGLDLPSPPTGASLKFYVPCKQCPPMKKGVSYLLMGQVEENRGPVLPPESFVVLHRPNQDQILTNLSKRKCPSQPVRAAASQD |
| Enzyme Length | 449 |
| Uniprot Accession Number | Q15113 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.; FUNCTION: C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (25); Chain (1); Disulfide bond (7); Domain (3); Glycosylation (2); Helix (2); Modified residue (1); Region (1); Signal peptide (1); Site (5); Turn (3) |
| Keywords | 3D-structure;Direct protein sequencing;Disulfide bond;Glycoprotein;Phosphoprotein;Reference proteome;Repeat;Secreted;Signal |
| Interact With | P05067; P13497; P39060; P20908; P07996; P07589; P18828; P43407; O35988 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 50; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:O08628 |
| Post Translational Modification | PTM: C-terminally processed at multiple positions. |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000255 |
| Structure 3D | NMR spectroscopy (1); X-ray crystallography (2) |
| Cross Reference PDB | 1UAP; 6FZV; 6FZW; |
| Mapped Pubmed ID | 10479448; 11313359; 12105202; 12393877; 12486138; 15817489; 16507574; 17446170; 17602227; 18164932; 18350290; 19361460; 19801683; 20207734; 20729553; 21569766; 21940633; 23550162; 23815790; 24117177; 25286301; 29683980; 30078642; 30393914; 3905801; 8636146; |
| Motif | |
| Gene Encoded By | |
| Mass | 47,972 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |