| IED ID | IndEnz0002000808 |
| Enzyme Type ID | protease000808 |
| Protein Name |
Procollagen C-endopeptidase enhancer 1 P14 Procollagen COOH-terminal proteinase enhancer 1 PCPE-1 Procollagen C-proteinase enhancer 1 Type 1 procollagen C-proteinase enhancer protein Type I procollagen COOH-terminal proteinase enhancer |
| Gene Name | Pcolce Pcpe1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MLPAALTSFLGPFLLAWVLPLARGQTPNYTRPVFLCGGDVTGESGYVASEGFPNLYPPNKKCIWTITVPEGQTVSLSFRVFDMELHPSCRYDALEVFAGSGTSGQRLGRFCGTFRPAPVVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRMEKAQGTLTTPNWPESDYPPGISCSWHIIAPSNQVIMLTFGKFDVEPDTYCRYDSVSVFNGAVSDDSKRLGKFCGDKAPSPISSEGNELLVQFVSDLSVTADGFSASYRTLPRDAVEKESALSPGEDVQRGPQSRSDPKTGTGPKVKPPTKPKSQPAETPEASPATQATPVAPAAPSITCPKQYKRSGTLQSNFCSSSLVVTGTVKTMVRGPGEGLTVTVSLLGVYKTGGLDLPSPPSGTSLKLYVPCRQMPPMKKGASYLLMGQVEENRGPILPPESFVVLYRSNQDQILNNLSKRKCPSQPRTAA |
| Enzyme Length | 468 |
| Uniprot Accession Number | Q61398 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Disulfide bond (6); Domain (3); Frameshift (1); Glycosylation (2); Modified residue (2); Region (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Direct protein sequencing;Disulfide bond;Glycoprotein;Phosphoprotein;Reference proteome;Repeat;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 41; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:O08628; MOD_RES 49; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:O08628 |
| Post Translational Modification | PTM: Processed from a 55 kDa form to 36 kDa and 34 kDa forms. |
| Signal Peptide | SIGNAL 1..24; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10479448; 10575226; 10723726; 10873381; 11013070; 12393877; 14610273; 15533722; 16141072; 16354695; 16602821; 1701491; 17683113; 17967808; 18799693; 18973680; 20439489; 20729553; 21677750; 24006456; 25249603; 27546376; 28746876; 32541010; 8765971; 8824813; 9126492; 9933570; |
| Motif | |
| Gene Encoded By | |
| Mass | 50,168 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |