IED ID | IndEnz0002000818 |
Enzyme Type ID | protease000818 |
Protein Name |
Rhomboid protein 1, mitochondrial EC 3.4.21.105 Mitochondrial distribution and morphology protein 37 Processing of cytochrome c peroxidase protein 1 |
Gene Name | PCP1 MDM37 RBD1 UGO2 YGR101W |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Enzyme Sequence | MSGVSSVMLGLRPATRIFFRSNISVSPSRTFVSYIGRSQSTSILKNAPNLEDNVTNLQKIIPKRFFSQTSILKSRWKPIFNEETTNRYVRLNRFQQYQQQRSGGNPLGSMTILGLSLMAGIYFGSPYLFEHVPPFTYFKTHPKNLVYALLGINVAVFGLWQLPKCWRFLQKYMLLQKDYVTSKISIIGSAFSHQEFWHLGMNMLALWSFGTSLATMLGASNFFSLYMNSAIAGSLFSLWYPKLARLAIVGPSLGASGALFGVLGCFSYLFPHAKILLFVFPVPGGAWVAFLASVAWNAAGCALRWGSFDYAAHLGGSMMGVLYGWYISKAVEKQRQRRLQAAGRWF |
Enzyme Length | 346 |
Uniprot Accession Number | P53259 |
Absorption | |
Active Site | ACT_SITE 256; /note=Nucleophile; ACT_SITE 313 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105; |
DNA Binding | |
EC Number | 3.4.21.105 |
Enzyme Function | FUNCTION: Mitochondrial rhomboid serine protease processing the mitochondrial membrane fusion regulator MGM1, and the cytochrome c peroxidase (CCP1). Required for TIM11 stability, ATP synthase complex assembly, mitochondrial morphology, cytochrome c (CYC1) storage and mitochondrial genome maintenance. {ECO:0000269|PubMed:11907266, ECO:0000269|PubMed:12417197, ECO:0000269|PubMed:12707284, ECO:0000269|PubMed:12774122, ECO:0000269|PubMed:12901865, ECO:0000269|PubMed:15125685}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (2); Chain (1); Mutagenesis (5); Transit peptide (1); Transmembrane (6) |
Keywords | Hydrolase;Membrane;Mitochondrion;Mitochondrion inner membrane;Protease;Reference proteome;Serine protease;Transit peptide;Transmembrane;Transmembrane helix |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:12774122, ECO:0000269|PubMed:12901865, ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:12774122, ECO:0000269|PubMed:12901865, ECO:0000269|PubMed:14562095}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | 12134146; 12791261; 15096522; 15979251; 16571363; 16725216; 16754953; 16778770; 17245427; 17263664; 17362197; 17445721; 17615298; 18604275; 18605900; 19019989; 19453275; 20045481; 20558178; 21299651; 21912603; 21936845; 22001671; 22658600; 22748693; 22808334; 24007978; 24099009; 24648523; 27502471; 27693354; |
Motif | |
Gene Encoded By | |
Mass | 38,815 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda | 3.4.21.105; |