| IED ID |
IndEnz0002000828 |
| Enzyme Type ID |
protease000828 |
| Protein Name |
Carboxypeptidase inhibitor SmCI
|
| Gene Name |
|
| Organism |
Sabellastarte magnifica (Feather duster) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Spiralia
Lophotrochozoa
Annelida
Polychaeta (polychaetes)
Sedentaria
Canalipalpata
Sabellida
Sabellidae
Sabellastarte
Sabellastarte magnifica (Feather duster)
|
| Enzyme Sequence |
ISVCDLPADRGQCTAYIPQWFFNKTTEDCEKFVYGGCQGNANRFETKDDCIANCGCNLPSKVGPCRVSARMWFHNPETEKCEVFIYGGCHGNANRFATETECQEVCDRYQKPGFCYQPSETGPCKGSFPRYYYDYEDGECKEFIYGGCEGNANNFETKESCENAC |
| Enzyme Length |
165 |
| Uniprot Accession Number |
P84875 |
| Absorption |
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| Active Site |
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| Activity Regulation |
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| Binding Site |
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| Calcium Binding |
|
| catalytic Activity |
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| DNA Binding |
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| EC Number |
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| Enzyme Function |
FUNCTION: Potent inhibitor of pancreatic carboxypeptidase A with a Ki of 27 nM, and of the serine proteases trypsin, chymotrypsin and pancreatic elastase, with Ki values of 6.9 nM, 1.83 nM and 4 nM, respectively. Does not inhibit cysteine and aspartic proteases. {ECO:0000269|Ref.1}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (12); Chain (1); Disulfide bond (9); Domain (3); Glycosylation (1); Helix (5); Turn (5) |
| Keywords |
3D-structure;Direct protein sequencing;Disulfide bond;Glycoprotein;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Repeat;Serine protease inhibitor |
| Interact With |
Q9UI42-1 |
| Induction |
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| Subcellular Location |
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| Modified Residue |
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| Post Translational Modification |
PTM: Contains 9 disulfide bonds. {ECO:0000269|Ref.1}. |
| Signal Peptide |
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| Structure 3D |
X-ray crystallography (1) |
| Cross Reference PDB |
4BD9;
|
| Mapped Pubmed ID |
23746805;
|
| Motif |
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| Gene Encoded By |
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| Mass |
18,650 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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