Detail Information for IndEnz0002000912
IED ID IndEnz0002000912
Enzyme Type ID protease000912
Protein Name Retrovirus-related Pol polyprotein from transposon 17.6
Includes: Protease
EC 3.4.23.-
; Reverse transcriptase
EC 2.7.7.49
; Endonuclease
Gene Name pol
Organism Drosophila melanogaster (Fruit fly)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly)
Enzyme Sequence TGRKFSATSLGKPQYITIKYKENNLKCLIDTGSTVNMTSKNIFDLPIQNTSTFIHTSNGPLIVNKSIIIPSKILFPTTNEFLLHPFSENYDLLLGRKLLAEAKATISYRDQEVTLYNNKYKLIEGIATHEQSHFQNVNMIPDTMLRQPNKISPILESDLYRLEHLNNEEKQRLCALLQKYHDIQYHEGDKLTFTNQTKHTINTKHNLPLYSKYSYPQAYEQEVESQIQDMLNQGIIRTSNSPYNSPIWVVPKKQDASGKQKFRIVIDYRKLNEITVGDRHPIPNMDEILGKLGRCNYFTTIDLAKGFHQIEMDPESVSKTAFSTKHGHYEYLRMPFGLKNAPATFQRCMNDILRPLLNKHCLVYLDDIIVFSTSLDEHLQSLGLVFEKLAKANLKLQLDKCEFLKQETTFLGHVLTPDGIKPNPEKIEAIQKYPIPTKPKEIKAFLGLTGYYRKFIPNFADIAKPMTKCLKKNMKIDTTNPEYDSAFKKLKYLISEDPILKVPDFTKKFTLTTDASDVALGAVLSQDGHPLSYISRTLNEHEINYSTIEKELLAIVWATKTFRHYLLGRHFEISSDHQPLSWLYRMKDPNSKLTRWRVKLSEFDFDIKYIKGKENCVADALSRIKLEETYLSEQTQHSAEEDNSDLIFITERPLNTFNRQVIFSKGPPDIKVTKYFKKHITQIFYDIMTREKAEQYLIDHFCGKKSALYIESDADFEVIQAAHKLAINTKYTKILRSTILLKNITTYAEFKELILTAHEKLLHPGIQKTTKLFGETYYFPNSQLLIQNIINECSICNLAKTEHRNTDMPTKTTPKPEHCREKFMIDIYSSEGKHYVSCIDIYSKFATLEEIKTKDWIECKNALMRIFNQLGKPKLLKADRDGAFSSLALKRWLESEEVELQLNTTKTGVADIERLHKTINEKIRIIKTSDDEETKLSKMETVLNIYNHKTKHDTTGQTPAHIFLYAGQPILDTQQNKENKINKINNDRVEYEVDTRYRKGPLQKGKLENPFKPTKNVEQTDSDHYKITNRNRITHYYKTQFKKRKKNNQLSISQAPGT
Enzyme Length 1058
Uniprot Accession Number P04323
Absorption
Active Site ACT_SITE 30; /note=For protease activity; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence={ECO:0000255|PROSITE-ProRule:PRU00405};
DNA Binding
EC Number 3.4.23.-; 2.7.7.49
Enzyme Function
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Domain (2)
Keywords Aspartyl protease;Endonuclease;Hydrolase;Nuclease;Nucleotidyltransferase;Protease;RNA-directed DNA polymerase;Transferase;Transposable element
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10331252; 10486975; 11591216; 23559253; 8026319;
Motif
Gene Encoded By
Mass 122,698
Kinetics
Metal Binding
Rhea ID RHEA:22508
Cross Reference Brenda