| IED ID | IndEnz0002000929 |
| Enzyme Type ID | protease000929 |
| Protein Name |
Peptidase inhibitor 15 PI-15 25 kDa trypsin inhibitor p25TI Cysteine-rich secretory protein 8 CRISP-8 SugarCrisp |
| Gene Name | PI15 CRISP8 P25TI |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MIAISAVSSALLFSLLCEASTVVLLNSTDSSPPTNNFTDIEAALKAQLDSADIPKARRKRYISQNDMIAILDYHNQVRGKVFPPAANMEYMVWDENLAKSAEAWAATCIWDHGPSYLLRFLGQNLSVRTGRYRSILQLVKPWYDEVKDYAFPYPQDCNPRCPMRCFGPMCTHYTQMVWATSNRIGCAIHTCQNMNVWGSVWRRAVYLVCNYAPKGNWIGEAPYKVGVPCSSCPPSYGGSCTDNLCFPGVTSNYLYWFK |
| Enzyme Length | 258 |
| Uniprot Accession Number | O43692 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727). May play a role in facial patterning during embryonic development (By similarity). {ECO:0000250|UniProtKB:Q98ST6, ECO:0000269|PubMed:8882727}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Glycosylation (3); Propeptide (1); Signal peptide (1) |
| Keywords | Developmental protein;Direct protein sequencing;Glycoprotein;Protease inhibitor;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8882727}. |
| Modified Residue | |
| Post Translational Modification | PTM: N-glycosylated. {ECO:0000305|PubMed:9473672}. |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 18464913; 29900129; 30638862; |
| Motif | |
| Gene Encoded By | |
| Mass | 29,065 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |