| IED ID | IndEnz0002000934 |
| Enzyme Type ID | protease000934 |
| Protein Name |
Peptidase inhibitor 16 PI-16 Cysteine-rich secretory protein 9 CRISP-9 PSP94-binding protein CD antigen CD364 |
| Gene Name | PI16 CRISP9 PSPBP PSEC0164 UNQ289/PRO328 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MHGSCSFLMLLLPLLLLLVATTGPVGALTDEEKRLMVELHNLYRAQVSPTASDMLHMRWDEELAAFAKAYARQCVWGHNKERGRRGENLFAITDEGMDVPLAMEEWHHEREHYNLSAATCSPGQMCGHYTQVVWAKTERIGCGSHFCEKLQGVEETNIELLVCNYEPPGNVKGKRPYQEGTPCSQCPSGYHCKNSLCEPIGSPEDAQDLPYLVTEAPSFRATEASDSRKMGTPSSLATGIPAFLVTEVSGSLATKALPAVETQAPTSLATKDPPSMATEAPPCVTTEVPSILAAHSLPSLDEEPVTFPKSTHVPIPKSADKVTDKTKVPSRSPENSLDPKMSLTGARELLPHAQEEAEAEAELPPSSEVLASVFPAQDKPGELQATLDHTGHTSSKSLPNFPNTSATANATGGRALALQSSLPGAEGPDKPSVVSGLNSGPGHVWGPLLGLLLLPPLVLAGIF |
| Enzyme Length | 463 |
| Uniprot Accession Number | Q6UXB8 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May inhibit cardiomyocyte growth. {ECO:0000250|UniProtKB:Q9ET66}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Chain (1); Compositional bias (1); Domain (1); Frameshift (1); Glycosylation (3); Natural variant (2); Region (4); Sequence conflict (2); Signal peptide (1) |
| Keywords | Alternative splicing;Direct protein sequencing;Glycoprotein;Protease inhibitor;Reference proteome;Secreted;Signal |
| Interact With | P27449; P60201-2; P0DN84; P55061; Q9H2L4; Q8N2M4 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15344909, ECO:0000269|PubMed:17062675, ECO:0000269|PubMed:22171320}. |
| Modified Residue | |
| Post Translational Modification | PTM: N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. {ECO:0000269|PubMed:15344909, ECO:0000269|PubMed:22171320}. |
| Signal Peptide | SIGNAL 1..27; /evidence=ECO:0000269|PubMed:15344909 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 20237162; 22533972; 27996045; 30365157; 31127857; |
| Motif | |
| Gene Encoded By | |
| Mass | 49,471 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |