Detail Information for IndEnz0002000960
IED ID IndEnz0002000960
Enzyme Type ID protease000960
Protein Name Pol polyprotein
Fragment
Gene Name pol
Organism Simian immunodeficiency virus agm.vervet (isolate AGM385) (SIV-agm.ver) (Simian immunodeficiency virus African green monkey vervet)
Taxonomic Lineage Viruses Riboviria Pararnavirae Artverviricota Revtraviricetes Ortervirales Retroviridae Orthoretrovirinae Lentivirus Simian immunodeficiency virus (SIV) Simian immunodeficiency virus - agm Simian immunodeficiency virus - agm.ver Simian immunodeficiency virus agm.vervet (isolate AGM385) (SIV-agm.ver) (Simian immunodeficiency virus African green monkey vervet)
Enzyme Sequence KEALVIWGELPTLELPVEREVWEQWWADYWQVSWIPEWDFVSTPPWLKLWYTLTKEPLAKEDVYYVDGACNRNSREGKAGYITQYGKQRVEKLENTTNQQ
Enzyme Length 100
Uniprot Accession Number P12501
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Domain (1); Non-terminal residue (2)
Keywords Aspartyl protease;DNA integration;DNA recombination;Endonuclease;Eukaryotic host gene expression shutoff by virus;Eukaryotic host translation shutoff by virus;Host gene expression shutoff by virus;Host-virus interaction;Hydrolase;Multifunctional enzyme;Nuclease;Nucleotidyltransferase;Protease;RNA-directed DNA polymerase;Transferase
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 12,024
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda