| IED ID | IndEnz0002000976 |
| Enzyme Type ID | protease000976 |
| Protein Name |
26S proteasome non-ATPase regulatory subunit 4 26S proteasome regulatory subunit RPN10 26S proteasome regulatory subunit S5A 54 kDa subunit of mu particle Multiubiquitin chain-binding protein p54 |
| Gene Name | Rpn10 PROS-54 Pros54 CG7619 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MVLESTMICFDNSDFQRNGDYFPTRLIVQRDGINLVCLTKLRSNPENNVGLMTLSNTVEVLATLTSDAGRIFSKMHLVQPKGEINLLTGIRIAHLVLKHRQGKNHKMRIVVFVGSPINHEEGDLVKQAKRLKKEKVNVDIVSFGDHGNNNEILTAFINALNGKDGTGSHLVSVPRGSVLSDALLSSPIIQGEDGMGGAGLGGNVFEFGVDPNEDPELALALRVSMEEQRQRQESEQRRANPDGAPPTGGDAGGGGGVSGSGPGNEESAGAENEANTEEAMLQRALALSTETPEDNLPDFANMTEEEQIAFAMQMSMQDAPDDSVTQQAKRPKTDEANAPMDVDEDYSEVIGDPAFLQSVLENLPGVDPQSEAVRDAVGSLNKDKDKKSDGKDSQKK |
| Enzyme Length | 396 |
| Uniprot Accession Number | P55035 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Binds and presumably selects ubiquitin-conjugates for destruction. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (2); Domain (4); Erroneous initiation (1); Region (3); Sequence conflict (1) |
| Keywords | Proteasome;Reference proteome;Repeat |
| Interact With | P52486; Q9VWD9 |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10893261; 11406394; 11739392; 11945175; 12421421; 12584246; 12861018; 12934013; 14605208; 14652013; 15053983; 15899868; 15946124; 16496002; 17075830; 17151602; 17429695; 18042644; 18493598; 18550751; 19064709; 19079254; 19148291; 19277057; 19543366; 19581588; 19654212; 20813047; 20861518; 21149573; 21251254; 21444692; 21973017; 22364263; 22417167; 22743648; 23071443; 23084835; 23161111; 23583758; 23805892; 24255095; 24292889; 24393533; 25152394; 25208640; 25294943; 25740935; 25776889; 25806519; 25916810; 26290570; 26405458; 26460970; 26526100; 26801178; 26870755; 27326929; 27582081; 27794539; 28596378; 28808087; 29855490; 30403998; 30478906; 30543682; 30816680; 31002009; 31320986; 31722958; 32344153; 32715147; 33242407; 8386175; 9256246; 9469929; |
| Motif | |
| Gene Encoded By | |
| Mass | 42,618 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.25.1; |