Detail Information for IndEnz0002001059
IED ID IndEnz0002001059
Enzyme Type ID protease001059
Protein Name Subtilisin-like protease 10
EC 3.4.21.-
Gene Name SUB10 ARB_06467
Organism Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Trichophyton Arthroderma benhamiae (Trichophyton mentagrophytes) Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Enzyme Sequence MFFFKGVVAVLSFFSAVNAAPFMKPNNGTRNYIPDSYIVLLKRDISHDDFELHKRWASDVHKRDVAKRGISFSGIGHSWATGSFRGYSGVFSRDTIEEIMKHEHVAHVERDQIGTSQGWVTQSGAPNWGLGRLSNNSPGNTDYTYDENAGGNGVVYVIDSGIDTMHPEFQGRATWGANFIDKNNVDCWNHGTHCAGIIGSATFGVAKLTALIAVKVLDCNGQGPYSAFVAGLHWATKHAQDNGFIGRAIINFSLGGDNSPAVNQALEEAQRAGIFVSAAAGNFGSDAGSITPGGAGLICVIGNSDDRDYRWTGQGPSNFGARVDIFAPGTNILSTIPGGGSGVMTGTSMAAPHVAGQAAILASISGSGFDLGAACAFFKNSASASVKNPGPNTTNKLLVNGANGTKGPKQGENKPNKPPGQDEQPGQNKPPSQNPPPGQNPPPGQNPPPEQPAPSPPANPGDEPNPDGQPYPGDQPNPGDSGPSWWMPSGGLQPPAWWNRRPSFGGWNRPMWWNRPLSVWKL
Enzyme Length 522
Uniprot Accession Number D4AQG0
Absorption
Active Site ACT_SITE 159; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 190; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 348; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.21.-
Enzyme Function FUNCTION: Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Compositional bias (2); Domain (2); Frameshift (1); Glycosylation (3); Propeptide (1); Region (1); Signal peptide (1)
Keywords Glycoprotein;Hydrolase;Protease;Reference proteome;Secreted;Serine protease;Signal;Virulence;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..19; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 55,200
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda