| IED ID | IndEnz0002001061 |
| Enzyme Type ID | protease001061 |
| Protein Name |
Trypsin-1 EC 3.4.21.4 Antryp1 |
| Gene Name | TRYP1 AGAP008296 |
| Organism | Anopheles gambiae (African malaria mosquito) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Nematocera Culicomorpha Culicoidea Culicidae (mosquitos) Anophelinae Anopheles Cellia Pyretophorus gambiae species complex Anopheles gambiae (African malaria mosquito) |
| Enzyme Sequence | MSNKIAILLAVLVAVVACAEAQANQRHRLVRPSPSFSPRPRYAVGQRIVGGFEIDVSDAPYQVSLQYNKRHNCGGSVLSSKWVLTAAHCTAGASPSSLTVRLGTSRHASGGTVVRVARVVQHPKYDSSSIDFDYSLLELEDELTFSDSVQPVGLPKQDETVKDGTMTTVSGWGNTQSAAESNAVLRAANVPTVNQKECNKAYSEFGGVTDRMLCAGYQQGGKDACQGDSGGPLVADGKLVGVVSWGYGCAQAGYPGVYSRVAVVRDWVRENSGV |
| Enzyme Length | 274 |
| Uniprot Accession Number | P35035 |
| Absorption | |
| Active Site | ACT_SITE 88; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 133; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 229; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4; |
| DNA Binding | |
| EC Number | 3.4.21.4 |
| Enzyme Function | FUNCTION: Major function may be to aid in digestion of the blood meal. {ECO:0000269|PubMed:7498434, ECO:0000269|PubMed:8335004}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Domain (1); Propeptide (1); Sequence conflict (7); Signal peptide (1); Site (1) |
| Keywords | Digestion;Disulfide bond;Hydrolase;Protease;Reference proteome;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | INDUCTION: By blood meal. {ECO:0000269|PubMed:8335004}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7498434, ECO:0000269|PubMed:8335004}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 29,057 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |