Detail Information for IndEnz0002001064
IED ID IndEnz0002001064
Enzyme Type ID protease001064
Protein Name Cell division inhibitor SulA
Gene Name sulA PA3008
Organism Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas Pseudomonas aeruginosa group Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Enzyme Sequence MQTSHSLPSAQLPLFQEAFWASNGAPLLDDVIDSPSSASIEEPAAFSELSLSGLPGHCLTLLAPILRELSEEQDARWLTLIAPPASLTHEWLRRAGLNRERILLLQAKDNAAALALSCEALRLGRSHTVVSWLEPLSRAARKQLSRAAQLGQAQSLNIRLG
Enzyme Length 161
Uniprot Accession Number Q9HZJ8
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (5); Chain (1); Helix (4); Region (3)
Keywords 3D-structure;Cell cycle;Cell division;DNA damage;Reference proteome;SOS response;Septation
Interact With
Induction INDUCTION: By DNA damage, as part of the SOS response. {ECO:0000250}.
Subcellular Location
Modified Residue
Post Translational Modification PTM: Is rapidly cleaved and degraded by the Lon protease once DNA damage is repaired. {ECO:0000250}.
Signal Peptide
Structure 3D X-ray crystallography (2)
Cross Reference PDB 1OFT; 1OFU;
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 17,476
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda