| IED ID | IndEnz0002001080 |
| Enzyme Type ID | protease001080 |
| Protein Name |
Urokinase-type plasminogen activator U-plasminogen activator uPA EC 3.4.21.73 Cleaved into: Urokinase-type plasminogen activator chain A; Urokinase-type plasminogen activator chain B |
| Gene Name | PLAU |
| Organism | Gallus gallus (Chicken) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken) |
| Enzyme Sequence | MKLIIFLTVTLCTLVTGLDSVYIRQYYKLSHKHRPQHRECQCLNGGTCITYRFFSQIKRCLCPEGYGGLHCEIDTNSICYSGNGEDYRGMAEDPGCLYWDHPSVIRWGDYHADLKNALQLGLGKHNYCRNPNGRSRPWCYTKRRYSIQETPCSTIEKCERTCGQRSFSKYFKIVGGSQAEVETQPWIAGIFQNIMGTDQFLCGGSLIDPCWVLTAAHCFYNPTKKQPNKSVYKVFLGKSILNTNDEHEQVFMVDEIISHPDFTDHTGGNDNDIALIRIRTASGQCAVESNYVRTVCLPEKNLNLYDNTWCEIAGYGKQNSYDIYYAQRLMSATVNLISQDDCKNKYYDSTRVTDNMVCAGDPLWETDACKGDSGGPMVCEHNGRMTLYGIVSWGDGCAKKNKPGVYTRVTRYLNWIDSNMNAVFTKSRSFREPK |
| Enzyme Length | 434 |
| Uniprot Accession Number | P15120 |
| Absorption | |
| Active Site | ACT_SITE 217; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 272; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 373; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.; EC=3.4.21.73; |
| DNA Binding | |
| EC Number | 3.4.21.73 |
| Enzyme Function | FUNCTION: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (3); Disulfide bond (12); Domain (3); Glycosylation (1); Region (1); Signal peptide (1) |
| Keywords | Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Kringle;Plasminogen activation;Protease;Reference proteome;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 24481918; |
| Motif | |
| Gene Encoded By | |
| Mass | 49,400 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |